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Chikungunya viral infection (CVI) is a mosquito-borne infection, caused by chikungunya virus (CHIKV), an alphavirus, belonging to the family Togaviridae. This infection causes febrile illness associated with high fever, rash, acute deliberating and persistent arthralgia. There is no licensed vaccine or specific treatment for this infection. Ivermectin (IVM), commonly-used antiparasitic, has been demonstrated to inhibit replication of CHIKV.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients received oral ivermectin, adjunctive to conventional treatment | Experimental |
| |
| Patients received conventional treatment | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ivermectin | Drug | 3-day 1 daily dose of 400 μg/kg oral ivermectin |
|
| Measure | Description | Time Frame |
|---|---|---|
| Day of fever clearance | 120 participants would be under Body Temperature Assessment - the staff would assess once daily until the fever clearance was below 38C and the measure proportion of patients with fever clearance in each day of assessment until fever clearance at least in 7 days | 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Day of virologic clearance | 120 participants would be obtained blood examination for virological testing every day until virological clearance at least in 7 days | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prince of Songkla University | Hat Yai | Changwat Songkhla | 90110 | Thailand |
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| ID | Term |
|---|---|
| D007559 | Ivermectin |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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