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| ID | Type | Description | Link |
|---|---|---|---|
| Cooperatio 31 fund | Other Grant/Funding Number | Charles University, Prague |
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Assessment of the association between human papillomavirus vaccination (HPV) and recurrences of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women undergoing conization.
The implementation of vaccination against human papillomavirus (HPV) in the national immunization program for the young age cohort was subsequently extended to previously unvaccinated adult women who underwent conization due to cervical intraepithelial neoplasia grade 2 or worse (CIN2+).
These women are offered HPV vaccination, often completed post-excision. Observational and clinical studies conducted between 2010 and 2023 have demonstrated that HPV vaccination contributes to a >70% reduction in CIN2+ recurrence in women after conization. However, the outcomes of these studies have not conclusively shown whether the adjuvant effect of HPV vaccination depends on the vaccine type (bi-, quadri-, or nona-valent), the timing and completeness of vaccination, and other factors.
This study aims to assess the mentioned factors and potentially reveal new ones, such as age, health status, etc. It is planned to be conducted using the laboratory records of women who underwent conization between 2010 and 2024, with their cervical screening examinations performed at the central laboratory UNILABS in Prague
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single cohort of women with cervical excision for CIN2+ | single cohort of women with cervical excision for CIN2+; those with HPV vaccination and those without HPV vaccination |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| vaccination against human papillomavirus infection (HPV vaccination) | Biological | Women with or without HPV vaccination before or after excision |
|
| Measure | Description | Time Frame |
|---|---|---|
| CIN2+ recurrence rate | CIN2+ recurrence rate - obtained from the number of women with this find-ing related the number of women with no finding within the time period since the conization; The recurrence rate of CIN2+ will be assessed in relation to vaccination, vaccine type, vaccination completeness, etc., using specific uni-variate analysis (incidence rate ratio) and multivariate analysis (incidence rate ratio or hazard ratio, as appropriate) | 2010-2024 |
| Measure | Description | Time Frame |
|---|---|---|
| CIN2+ recurrence frequency | CIN2+ recurrence frequency - percentage proportion of women with this finding related to all women in follow-up; The recurrence frequency of CIN2+ will be assessed in relation to vaccination, vaccine type, vaccination completeness, etc., using specific univariate analysis (odds ratio, relative risk) and multivariate analysis (odds ratio, relative risk, as appropriate) | 2010-2024 |
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Inclusion Criteria:
Exclusion Criteria:
- Women who underwent hysterectomy after conization.
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The population consists of women who underwent conization for CIN2+, and the laboratory examination of conization and other samples was conducted at the central laboratory of UNILABS. The follow-up period for the population must be at least 6 months, with at least one negative finding before a recurrence of CIN2+ is identified.
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| Name | Affiliation | Role |
|---|---|---|
| Marek Petráš, assoc.prof. | Department of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University, Prague, Czech Republic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Epidemiology and Biostatistics, Third Faculty of Medicine, Charles University | Prague | 10000 | Czechia | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37553234 | Result | Petras M, Dvorak V, Lomozova D, Macalik R, Neradova S, Dlouhy P, Malinova J, Rosina J, Lesna IK. Timing of HPV vaccination as adjuvant treatment of CIN2+ recurrence in women undergoing surgical excision: a meta-analysis and meta-regression. Sex Transm Infect. 2023 Dec;99(8):561-570. doi: 10.1136/sextrans-2023-055793. Epub 2023 Aug 8. |
| Label | URL |
|---|---|
| Timing of HPV vaccination as adjuvant treatment of CIN2+ recurrence in women undergoing surgical excision: a meta-analysis and meta-regression | View source |
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| Unilabs Pathology K.S |
| Prague |
| 16000 |
| Czechia |
| ID | Term |
|---|---|
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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