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The current project was designed to examine the effects of BCAA metabolic dysfunction on cardiac function in septic patients.
Patients with sepsis and with/without type 2 diabetes will be included. Patients prospectively collected the following indicators in the intensive care unit: 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. Additionally, the investigators will collect the peripheral blood at preoperative, day 1, day 3, and day 5 after surgery. Peripheral blood plasma and PBMCs were separated by differential centrifugation: the concentration of BCAAs in serum and PBMCs; the expression of PBMCs BCAAs metabolic enzymes BCAT 1, BCKDH, and PP 2 Cm by WB; and the levels of AST, ALT, LDH, CK, and CK-MB
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who are diagnosed as sepsis, with type 2 diabetes. | 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. |
| |
| Patients who are diagnosed as sepsis, without type 2 diabetes. | 1. myocardial injury-related biomarkers: troponin T and B natriuretic peptide levels; 2. cardiac structure-related indicators: the size of the left and right ventricle, left ventricular ejection fraction, etc.3. septic cardiomyopathy incidence: Troponin T>0.01ng/ml is the standard for the diagnosis of septic cardiomyopathy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Effect of BCAAs metabolic dysfunction on cardiac function in sepsis | Other | Effect of BCAAs metabolic dysfunction on cardiac function in sepsis |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of Sepsis induced cardiomyopathy | Diagnostic criteria for Sepsis induced cardiomyopathy, TroponinT > 0.01 ng/ml | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma levels of TroponinT | If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis. | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first |
| Plasma levels of type B natriuretic peptide |
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Inclusion Criteria:
- patients diagnosed with sepsis with or without type 2 diabetes
Exclusion Criteria:
- patients with immunodeficient diseases patients who accept glucocorticoid or immunosuppressant patients with an age younger than 18 years patients who cannot provide informed consent
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Patients with sepsis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chunling Jiang, PhD | Contact | 18980601096 | jiangchunling@scu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Fengmin Luo, PhD | West China Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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If multiple measurements is available during the first 7 days, the mean measurement will be used for analysis. |
| up to 7 days post-ICU admission, or at hospital discharge, whichever comes first |
| ejection fraction | If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis. | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first |
| Left ventricular and right ventricular size | If multiple measurements is available during the first 7 day, the mean measurement will be used for analysis. | up to 7 days post-ICU admission, or at hospital discharge, whichever comes first |
| D013568 |
| Pathological Conditions, Signs and Symptoms |