Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| FrieslandCampina | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
This study aims to investigate how GOS food supplement influences the gut-microbiome-brain axis to improve emotion regulation skills and cognition in a sample of children and adolescents (aged 6-14 years).
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Galacto-oligosaccharide | Dietary Supplement | Single 7g dose daily for 28 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in trait anxiety. | Self report instrument: state-trait anxiety measure for children (STAIC) - Trait scale. | End of treatment (4 weeks), Follow up (8 weeks). |
| Changes in emotion processing. | Performance on behavioural task: emotional dot-probe task. | End of treatment (4 weeks), Follow up (8 weeks). |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in depression. | Self report instrument: child depression inventory (CDI). | End of treatment (4 weeks), Follow up (8 weeks). |
| Changes in attention networks. | Performance on behavioural task: attention network test (ANT) adapted for use by children. |
| Measure | Description | Time Frame |
|---|---|---|
| Parental anxiety: covariate of child outcome. | Self report instrument: state-trait anxiety inventory (STAI) - Trait scale. | Baseline, End of treatment (4 weeks), Follow up (8 weeks). |
| Parental emotion processing: covariate of child outcome. |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Surrey | Guildford | Surrey | GU2 7XH | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40025494 | Derived | Johnstone N, Cohen Kadosh K. Indicators of improved emotion behavior in 6-14-year-old children following a 4-week placebo controlled prebiotic supplement intervention at home with a parent. Nutr J. 2025 Mar 1;24(1):34. doi: 10.1186/s12937-025-01098-5. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D000080103 | Emotional Regulation |
| ID | Term |
|---|---|
| D000068356 | Self-Control |
| D012919 | Social Behavior |
| D001519 | Behavior |
Not provided
Not provided
| ID | Term |
|---|---|
| C072242 | 4'-galactooligosaccharide |
| C008315 | maltodextrin |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Maltodextrin |
| Dietary Supplement |
Single 7g dose daily for 28 days |
|
| End of treatment (4 weeks), Follow up (8 weeks). |
| Changes in nutrient intake | Self report instrument: food diary completed over 4 days, average intakes calculated. | End of treatment (4 weeks), Follow up (8 weeks). |
Performance on behavioural task: emotional dot-probe task.
| Baseline, End of treatment (4 weeks), Follow up (8 weeks). |
| Parent depression | Self report instrument: Becks depression inventory (BDI-II). | Baseline, End of treatment (4 weeks), Follow up (8 weeks). |
| Parent attention networks | Performance on behavioural task: attention network test. | Baseline, End of treatment (4 weeks), Follow up (8 weeks). |