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The primary purpose of this study is to retrospectively identify the clinical characteristics of abdominal lymphatic malformations (ALMs) in our single center in China. The second objective of this study is to retrospectively compare the epidemiological features, clinical presentations, cyst properties, surgical treatments, and risk factors for preoperative complications of ALMs between paediatric participants and adult participants.
Lymphatic malformations (LMs) are vascular anomalies that arise from abnormal embryonic development of the lymphatic system and can present as dilated lymphatic channels or cysts lined by lymphatic endothelial cells. Abdominal lymphatic malformations (ALMs) are rare entities that account for fewer than 10% of LMs and may occur not only in the tissues or organs in the abdominal cavity, such as the mesentery, spleen and pancreas but also in the retroperitoneal space. ALMs can manifest as an infection, chronic abdominal discomfort, acute abdomen, or fatal disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Paediatric group | The investigators defined participants under 14 years old as the paediatric group. |
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| Adult group | The investigators defined participants over 14 years old as the adult group. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants. | Other | Compare the epidemiological characteristics, clinical presentations, surgical treatments and risk factors for preoperative complications of ALMs between paediatric and adult participants. |
| Measure | Description | Time Frame |
|---|---|---|
| The location of abdominal lymphatic malformations in participants | Location included mesentery, retroperitoneum, omentum, spleen, etc. | From 2009.1 to 2022.12 |
| The morphologic subtypes of abdominal lymphatic malformations in participants | Morphologic subtypes included macrocystic, microcystic and mixed type. | From 2009.1 to 2022.12 |
| The presentations at diagnosis of abdominal lymphatic malformations in participants | Presentations at diagnosis included chronic pain, acute abdominal disease and incidental health checkup. | From 2009.1 to 2022.12 |
| The largest diameter of abdominal lymphatic malformations in participants | Largest diameter in centimeters was mainly measured by intraoperative detections. | From 2009.1 to 2022.12 |
| The preoperative complications of abdominal lymphatic malformations in participants | Preoperative complications included intestinal volvulus, haemorrhage, infection, rupture and compression. | From 2009.1 to 2022.12 |
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of abdominal lymphatic malformations in paediatric and adult group | Incidence of abdominal lymphatic malformations in paediatric and adult group was retrospectively compared. | From 2009.1 to 2022.12 |
| The number of female patients with abdominal lymphatic malformations in paediatric and adult group |
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Inclusion Criteria:
Exclusion Criteria:
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In this study, The investigators retrospectively collected and compared the data related to the preoperative information, intraoperative findings and postoperative pathological analysis of the enrolled abdominal lymphatic malformations for paediatric and adult participants.
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| Name | Affiliation | Role |
|---|---|---|
| Yi Ji, Ph.D. | West China Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital of Sichuan University | Chengdu | Sichuan | 610041 | China |
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| ID | Term |
|---|---|
| D044148 | Lymphatic Abnormalities |
| D008202 | Lymphangioma |
| D000006 | Abdomen, Acute |
| ID | Term |
|---|---|
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D012307 | Risk Factors |
| ID | Term |
|---|---|
| D012306 | Risk |
| D011336 | Probability |
| D013223 | Statistics as Topic |
| D004812 | Epidemiologic Methods |
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|
Number of female patients with abdominal lymphatic malformations in paediatric and adult group was retrospectively compared. |
| From 2009.1 to 2022.12 |
| The rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group | Rate of abdominal lymphatic malformations with acute abdomen in paediatric and adult group was retrospectively compared. | From 2009.1 to 2022.12 |
| The rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group | Rate of abdominal lymphatic malformations located in mesentery for paediatric and adult group was retrospectively compared. | From 2009.1 to 2022.12 |
| The risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group. | Risk factors of preoperative complications of abdominal lymphatic malformations for paediatric and adult group was retrospectively compared. | From 2009.1 to 2022.12 |
| D018190 | Neoplasm, Lymphatic Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D015746 | Abdominal Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |
| D008919 |
| Investigative Techniques |
| D015984 | Causality |
| D015981 | Epidemiologic Factors |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D017531 | Health Care Evaluation Mechanisms |
| D011634 | Public Health |
| D004778 | Environment and Public Health |