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Transthyretin amyloid cardiomyopathy (ATTR-CM) is a commonly undiagnosed and potentially fatal disease. Contemporary studies on this condition often underrepresent the female gender and diverse patient populations. This registry retrospectively evaluated patients referred for 99mTc-pyrophosphate (PYP) Single Photon Emission Computed Tomography (SPECT) between 2014 and 2023 at Montefiore-Einstein in the Bronx. The patient population is racially and ethnically diverse and with a high proportion of females. Demographic, clinical (e.g. comorbidities), laboratory, echocardiographic, hospitalization, and mortality data were collected for each patient.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients referred for 99mTc-pyrophosphate Single Photon Emission Computed Tomography | Patients with suspected transthyretin cardiac amyloidosis referred for 99mTc-pyrophosphate Single Photon Emission Computed Tomography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 99mTc-pyrophosphate Single Photon Emission Computed Tomography | Diagnostic Test | All patients underwent 99mTc-pyrophosphate Single Photon Emission Computed Tomography and had a baseline echocardiogram |
| Measure | Description | Time Frame |
|---|---|---|
| ATTR-CM Diagnosis | The number of patients who underwent a PYP SPECT scan diagnostic of ATTR-CM will be assessed and reported | During the index PYP scan within the study time frame parameters of the retrospective review (between 2014 and 2023) |
| Mortality | The number of patients who died from all-cause mortality will be tabulated and reported | Within the study time frame parameters of the retrospective review (between 2014 and 2023) |
| Measure | Description | Time Frame |
|---|---|---|
| Heart failure hospitalizations | The number of patients admitted to the hospital with a primary diagnosis of heart failure will be tabulated and reported | Within the study time frame parameters of the retrospective review (between 2014 and 2023) |
| Total Hospitalizations |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients referred for PYP SPECT at Montefiore Medical Center between 2014 and 2023 who had a transthoracic echocardiogram in our medical records.
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| Name | Affiliation | Role |
|---|---|---|
| Leandro Slipczuk, MD | Montefiore Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montefiore Health System | The Bronx | New York | 10467 | United States |
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| Label | URL |
|---|---|
| Performance of Clinical Scoring Systems in the Diagnosis of Transthyretin Amyloid Cardiomyopathy in a Diverse Patient Cohort | View source |
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The number of patients admitted to the hospital with any diagnosis will be tabulated and reported |
| Within the study time frame parameters of the retrospective review (between 2014 and 2023) |