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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA055259-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration.
Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration. In the encoding session, participants play the producer for a game show. On each trial, participants are shown a trial-unique contestant (2s), and then they select one of 3 presented doors to reveal a hidden object (4 seconds). The selected door is then highlighted (2-4s), which is then removed to show a trial-unique object image, which is framed as a prize (2s). On exploration trials, participants actively select which door to open. On control trials, the participant is forced to select a highlighted door, fostering passive rather than active information seeking. Unbeknownst to participants, there is no relationship between selected doors and revealed objects, as objects are pre-selected for each trial. Thus, timing, motor demands, and visual information are fixed across conditions. Participants will complete 3 runs of both the exploration and control condition, with each run containing 20 trials. Temporal jitters are placed between cues and outcomes and between trials, as determined by design optimization software77. Run will be pseudo-randomized across participants so no more than 2 runs of the same condition will appear in a row. Following encoding, participants will complete immediate and delayed item-associative memory test. On each trial of the memory test, participants will view the characters presented during exploration and control trials as well as new foil characters. If a participant indicates that they have previously seen a character before, the participants will be shown three object images encountered during encoding, and decide which item served as a prize for that specific character. In this way, the investigators can resolve memory for contestants (i.e., cues), and associative binding across contestants and prizes (i.e., cue-outcome). Participants memory will be tested for half the stimuli immediately and at a 24-hour delay.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Motivation | Experimental | Trials in which participants are motivated by agency or not in a within-subjects design |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Task Instructions | Behavioral | Participants will be given cued instructions as to whether they are in a high or low motivation condition |
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| Measure | Description | Time Frame |
|---|---|---|
| Mesolimbic-hippocampal Interactions | Functional Magnetic Resonance Imaging Activation characterizing mesolimbic-hippocampal interactions as queried using representational simliarity analysis across these two regions of interest. In this analysis, we explore the pattern similarity within the same set of regions (mesolimbic and hippocampal regions) across different trial types. In this way the standard unit for these values reflect a correlation that is summarized by a standardized beta-value extracted from a nested mixed effects model. | During Procedure |
| Episodic Memory | Item and Associative memory for memoranda shown during the task. This measure reflects the percent of memory test retrieval trials in which participants were able to successfull remember an item and its associated features compared across a high and low reward condition. | 24-hours, we administered our memory test 24 hours after the first session but this is the first time we are administering this test. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Temple University | Philadelphia | Pennsylvania | 19122 | United States |
Deidentified data will be shared on the open science framework.
Data will be shared within 1 year of study completion, and it will be available for at least 10 years.
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Of the 76 participants that were recruiteted, 0 were excluded prior to assignment.
Recruitment Status: Completed Study Start Date: October 25, 2023
Primary Completion Date: February 09, 2024
Study Completion Date: February 09, 2024
Enrollment (Actual): 76 participants
Study Locations:
Temple University, Philadelphia, PA, United States
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| ID | Title | Description |
|---|---|---|
| FG000 | Motivation | Trials in which participants are motivated by agency or not in a within-subjects design Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Motivation | Trials in which participants are motivated by agency or not in a within-subjects design Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Self-report of age. |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Mesolimbic-hippocampal Interactions | Functional Magnetic Resonance Imaging Activation characterizing mesolimbic-hippocampal interactions as queried using representational simliarity analysis across these two regions of interest. In this analysis, we explore the pattern similarity within the same set of regions (mesolimbic and hippocampal regions) across different trial types. In this way the standard unit for these values reflect a correlation that is summarized by a standardized beta-value extracted from a nested mixed effects model. | This is the entire population that continued the protocol. While in typical clinical trials there may be a comparison across arms of a group, this study utilized a within-subjects design, thus we were comparing conditions within one group of participants. In this way, our overall participant pool reflects a single arm and our statistical comparisons were made across conditions within this single group. | Posted | Mean | Standard Error | standardized beta-value | During Procedure |
|
24 hours following baseline
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Motivation | Trials in which participants are motivated by agency or not in a within-subjects design Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Vishnu Murty | University of Oregon | 740-6328932 | murty@uoregon.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | Feb 11, 2026 | Feb 11, 2026 | Prot_SAP_ICF_000.pdf |
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| Participants |
|
| Sex: Female, Male | Count of Participants | Participants |
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| Race (NIH/OMB) | Self-report | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Motivation |
Trials in which participants are motivated by agency or not in a within-subjects design Task Instructions: Participants will be given cued instructions as to whether they are in a high or low motivation condition |
|
|
|
| Primary | Episodic Memory | Item and Associative memory for memoranda shown during the task. This measure reflects the percent of memory test retrieval trials in which participants were able to successfull remember an item and its associated features compared across a high and low reward condition. | This is the entire population that continued the protocol. While in typical clinical trials there may be a comparison across arms of a group, this study utilized a within-subjects design, thus we were comparing conditions within one group of participants. In this way, our overall participant pool reflects a single arm and our statistical comparisons were made across conditions within this single group. | Posted | Mean | Standard Error | Proportion of Trials Correct | 24-hours, we administered our memory test 24 hours after the first session but this is the first time we are administering this test. |
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| 0 |
| 74 |
| 0 |
| 74 |
| 0 |
| 74 |
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