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This study was conducted on thirty children aged from12 months to 18 years newly diagnosed with drug resistant epilepsy and following up at Pediatric Nutrition and Neurology Outpatient Clinics assigned randomly into 2 groups, group1: patients who started ketogenic diet with L-carnitine and group2: patients who started ketogenic diet only.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ketogenic diet with L - Carnitine supplementation. | Experimental | Patients with drug resistant epilepsy who received ketogenic diet with L - Carnitine supplementation. |
|
| ketogenic diet. | Active Comparator | Patients with drug resistant epilepsy who received ketogenic diet only. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L- Carnitine | Dietary Supplement | L-carnitine was taken after feeds in the form of tablets or dissolved tablets in a dose of 50 mg/kg/day, with maximum dose of 2 g/day. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment the effect of L-carnitine supplementation on gastric emptying in children with drug resistant epilepsy (DRE) on ketogenic diet (KD). | Antral length measurement using abdominal ultrasonography. | At time of enrollment and 3 months of intervention. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| May F Nassar, MD | Professor of pediatrics, Faculty of Medicine, Ain shams University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine-Ain Shams University | Cairo | Abbasia | 1181 | Egypt |
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| ID | Term |
|---|---|
| D002331 | Carnitine |
| D055423 | Diet, Ketogenic |
| ID | Term |
|---|---|
| D050337 | Trimethyl Ammonium Compounds |
| D000644 | Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
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| ketogenic diet | Other | ketogenic diet (KD) initiated under supervision of expert physician who considered patient's age, type of feeding, needs and preferences of the child and his/her family to select the type and initial ratio of KD therapy, KD ratio ranged from 1:1 to 4:1 of lipids to carbohydrates plus proteins in grams. |
|
| D050528 |
| Diet, Carbohydrate-Restricted |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |