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Chemical peels are resurfacing procedures where chemical agent causes controlled exfoliation of the skin, followed by regeneration and remodelling of the epidermis and dermis layers. Chemical peels can be used to treat various skin condition, such as skin aging, pigmentary disorders, and skin texture disorders. The use of moisturizer after chemical surgery can help speed up the wound healing process and repair the skin barrier. TCA chemical peel has more side effects than other chemical peel solutions. The risk of complications after TCA chemical surgery on Fitzpatrick IV-VI skin types is also higher, especially post-inflammatory hyperpigmentation. There is no specific recommendations regarding the type of moisturizer that can be used after TCA chemical peels. This study aims to assess the effectiveness of a cream containing spent grain wax, argan oil, and shea butter in reducing TCA peel side effects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cream Containing Spent Grain Wax Extract, Argan Oil, and Shea Butter (Ezerra Cream) | Active Comparator | Ezerra cream The creams are applied to the face twice daily (0,5 Finger Tip Unit/FTU), immediately after washing. group A (intervention cream on the right side of the face and control cream on the left side of the face) and group B (intervention cream on the left side of the face and control cream on the right side of the face). |
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| Vehicle cream | Placebo Comparator | Vehicle cream was prepared by the Pharmacy Department of Faculty of Medicine Universitas Indonesia and has similar consistency, color, and scent as the intervention cream. The creams are applied to the face twice daily (0,5 Finger Tip Unit/FTU), immediately after washing. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ezerra cream | Drug | The research subjects were divided into 2 groups: group A (intervention cream on the right side of the face and control cream on the left side of the face) and group B (intervention cream on the left side of the face and control cream on the right side of the face). The test material consists of a cream containing a mixture of spent grain wax extract, shea butter, and argan oil, along with a vehicle cream. Vehicle cream was prepared by the Pharmacy Department of Faculty of Medicine Universitas Indonesia and has similar consistency, color, and scent as the intervention cream.The creams are applied to the face twice daily (0,5 FTU), immediately after washing, in equal amounts on each side of the face. The creams are applied for 7 days, and participants are instructed to use appropriate sunscreen. |
| Measure | Description | Time Frame |
|---|---|---|
| Transepidermal water loss | Baseline (30 minutes after peeling), day 3, and day 7 | |
| Skin Capacitance | Baseline (30 minutes after peeling), day 3, and day 7 | |
| Erythema index | Baseline (30 minutes after peeling), day 3, and day 7 |
| Measure | Description | Time Frame |
|---|---|---|
| global investigator assessment | comprised individual ratings of erythema, desquamation, edema, each on 4-point-scale (0-None; 1-Mild; 2-Moderate, 3-Severe | Baseline (30 minutes after peeling), day 3, and day 7 |
| subject self-assessment |
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Inclusion Criteria:
women, 30 - 60 years old with facial skin aging underwent chemical peeling with TCA 15%, have received priming with topical retinoic acid 0.05%, for at least 2 weeks and its use has been discontinued three days before chemical peel.
Exclusion Criteria:
Pregnant or lactating women, patients who received hormonal therapy, immunosuppressants, allergic to any of treatment ingredients, had active skin diseases on the face (acne vulgaris, seborrheic dermatitis, dll), history of keloid/hypertrophic scar, open wound, active infection, or history of recurrent herpes simplex
Female
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| Name | Affiliation | Role |
|---|---|---|
| Dina Kusumawardhani | Indonesia University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Universitas Indonesia | Jakarta | 10430 | Indonesia |
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A randomized, placebo-controlled, double-blinded, split face trial on women undergoing TCA 15% chemical peels.
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double-blinded
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comprised individual ratings of erythema, desquamation, burning, pain, and itch, each on a 4-point-scale (0-None; 1-Mild; 2-Moderate, 3-Severe).
| Baseline (30 minutes after peeling), day 3, and day 7 |