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The aim of the study is to see if endogenous exhaled Nitric Oxyde (eNO) concentrations measured are significantly higher in ARDS patients admitted in ICU ; compared to control subjects in good health with no lung disease or global inflammation, operated under general anesthesia (i.e. intubated and ventilated) for thyroid or parathyroid.
The measurement of endogenous exhaled NO is monitored using a laser spectrometer machine connected to the expiratory circuit of the respirator. The measure is non-invasive and made by sampling expiratory gaz like for capnography.
In control subjects, the measurement period corresponds to the first ten minutes after induction of anesthesia (with intubation) before surgical incision.
In ARDS patients in intensive care, the measurement of eNO is made in the first twenty-four hours after intubation and ventilation of the patient with mechanical respirator.
The primary endpoint is a significantly higher eNO concentration in patients suffering from Acute Respiratory Distress Syndrome (ARDS).
Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria: PaO2/FiO2; ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ARDS patients | ARDS patients admitted in ICU ;intubated and mechanically ventilated for less than 24 hours |
| |
| Control group | Healthy subjects without pulmonary nor inflammatory pathology, who underwent a benign surgical procedure (thyroid or parathyroid surgery) requiring general anesthesia with intubation and mechanical ventilation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non invasive measure of endogenous exhaled Nitric Oxyde in exhaled gaz, by a laser spectrometer | Other | A sample of exhaled gases is taken from the expiratory part of the respirator circuit (same way as a capnometry measurement). A laser spectrometer continuously and non-invasively monitors online the concentrations of endogenous NO exhaled by patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Endogenous exhaled Nitric Oxyde (eNO) | The primary endpoint is a significantly higher eNO concentration in ARDS patients. | Measurement of eNO over a period of 10 minutes just after induction of anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| Secondary endpoints will assess correlations between eNO concentrations and usual ARDS severity criteria | ARDS severity criteria are: Partial arterial pressure of oxygen divided by inspired fraction of oxygen (PaO2/FiO2); ventilator-free days; length of stay in intensive care and all-cause hospital mortality at 30 days. | Measurement of eNO over a period of 10 minutes within the first 24 hours after intubation |
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Inclusion Criteria:
For ARDS patients :
For control patients :
Exclusion Criteria:
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ARDS patients (from any cause) in ICU Control group : healthy patients (ASA I or II) operated for a minor surgery (thyroid or parathyroid)
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| Name | Affiliation | Role |
|---|---|---|
| Raphael BRIOT, MD ; PhD | Laboratoire TIMC - Team PRETA UMR CNRS-UGA 5525 ; Grenoble Alpes University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Grenoble Alpes | Grenoble | 38000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33477122 | Background | Chollier T, Richard L, Romanini D, Brouta A, Martin JL, Moro C, Briot R, Ventrillard I. Monitoring of endogenous nitric oxide exhaled by pig lungs during ex-vivo lung perfusion. J Breath Res. 2021 Feb 11;15(2). doi: 10.1088/1752-7163/abde95. |
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In this single-center observational study, anonymized data are collected and centralized by the principal investigator before being analyzed by the team of statisticians.
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| D011654 | Pulmonary Edema |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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