Effects of the Use of Probiotics on the Intestinal Microbiota of Patients With Gastric Cancer

Effects of the Use of Probiotics on the Intestinal Microbiota, Clinical-Nutritional and Immunological Status of Patients Gastrectomized for Gastric Cancer: A Randomized Clinical Trial

The objective of this randomized controlled, prospective clinical study, composed of 5 groups, G1, G2, G3, G4 and G5 is [Evaluate the intestinal microbiota profile, nutritional, immunological status and inflammatory profile, before and after total or partial removal surgery (gastrectomies) for gastric cancer, in a patient using probiotic supplements.] The main questions it aims to answer are:

• probiotics are capable of modulating the immune response and microbiota in cancer patients who will undergo surgery
• surgery itself alters the immunological pattern and microbiota of cancer patients Participants will be divided into groups for evaluation and the G1 intervention group will take probiotic capsules.

The researchers will compare groups G1, G2 with G3 (negative control group) to see if there are differences between using probiotics or not, in controlling the immune response and if there are significant changes in their intestinal microbiota. Groups G4 and G5 will also be compared, where in these we will only measure the power of the use of probiotics in reducing surgical complications in the postoperative period.

Inclusion Criteria:

• Patients with indication for total or partial gastrectomy;
• Ages from 18 years old.

Exclusion Criteria:

• Palliative patients
• Use of probiotics and prebiotics in the last 15 days;
• Patients who are unable to complete all monitoring steps;
• AIDS patients;
• Diabetic patients;
• Pregnant patients;
• Patients with Autoimmune Diseases;
• Patients with Liver Diseases;
• Patients with Kidney Disease;
• Patients with Inflammatory Bowel Diseases.
• Patients who have MCP (pacemaker),
• Patients with severe Edema,
• Patients with titanium plates in any limb of the body
• Patients who for some reason had their surgeries suspended during follow-up.
• Patients undergoing mechanical colon preparation in the last 30 days.
• Patients not resident/domiciled in Amazonas.