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| Name | Class |
|---|---|
| The Affiliated Hospital of Qingdao University | OTHER |
| First Hospital of China Medical University | OTHER |
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
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The present multicentre retrospective cohort study aimed to investigate the association between intraoperative administration of dexmedetomidine and postoperative mortality in hospitals.
The investigators set out to test the hypothesis that perioperative dexmedetomidine use, as an adjunct to general anesthesia, diminishes postoperative mortality in hospitals across all categories of surgical patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| dexmedetomidine | dexmedetomidine group: abbreviated for dexmedetomidine group, refers to the group with intraoperative administration of dexmedetomidine adjunct to propofol |
| |
| non-dexmedetomidine | non-dexmedetomidine group: abbreviated for non-dexmedetomidine group, refers to the group without intraoperative administration of dexmedetomidine adjunct to propofol |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | whether intraoperative dexmedetomidine was administered adjunct to propofol for patients undergoing surgeries under general anaesthesia |
|
| Measure | Description | Time Frame |
|---|---|---|
| in-hospital all-cause mortality | in-hospital deaths or discharged to hospice (or home) | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| length of postoperative hospital stay | in days | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year |
| admission to the intensive care unit (ICU) |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients (aged ≥18 years) admitted for surgical procedures under general anaesthesia with propofol at the five participating hospitals from January 1, 2014 to June 30, 2018.
IPD will not be available
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Sir Run Run Shaw Hospital | OTHER |
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unplanned admissions
| from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year |
| adverse events after surgery | severe stroke, the necessity for renal replacement therapy (RRT), myocardial infarction, ventilator-associated pneumonia (VAP), acute respiratory distress syndrome (ARDS), unplanned reoperation due to postoperative complications, sepsis, and multi-organ dysfunctions (MODs), if any | from the time of end of surgery until time of documented hospital discharge or time of death, whichever came first, assessed up to 1 year |