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| Name | Class |
|---|---|
| SolidarMed | OTHER |
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The primary research objective is to examine how uncertainty towards a new medical treatment changes in patients when a partner (can be any close other, i.e. romantic partner, family member, or a close friend) supports the new treatment choice and is willing to be involved in the patient's treatment. I hypothesize that when the patients know that their partner supports uptake of the new medical treatment and will physically accompany them to the visit, patients will (1) experience lower levels of uncertainty and (2) report a higher likelihood of participating in a new treatment in the future, as compared to patients who face the decision about the new treatment alone.
Host trial: Uncertainty survey experiment
This study uses a survey experiment with a hypothetical scenario (vignette) to test the concept of uncertainty and the impact of partner involvement in a hypothetical new medical treatment in patients seeking healthcare in the Butha Buthe district hospital. Specifically, this host trial will be a single-blinded randomized survey experimental design. This means that there will be two versions of the vignette and participants will be randomly given only one version (1:1 allocation). The participants will not be made aware that there is a different version of the vignette but the researchers will be aware of which version the participant receives. The difference between the vignettes (called behavioral manipulation) is whether or not the partner endorses the hypothetical new medical treatment related to the patient's current illness. See the Study measures Section for the specific vignettes.
Study Within a Trial (SWAT): Impact of the researcher's attire on recruitment rates
Within the host trial, the nested study on researcher's attire will take place as a "Study Within A Trial" or SWAT. SWAT is an increasingly recognized method of research that aims to improve the research methodology within an existing trial. The SWAT on researcher attire will take place in the recruitment phase of the host experiment with day-based cluster randomization between white coat versus casual attire assignment. These attire assignments will be given along with the given week's recruitment assignments to the two Basotho research assistants who will work on the host trial. The nested study does not impact the procedures of the survey experiment. Researcher's attire during recruitment will remain the same throughout the survey delivery until the end of the participant's study visit.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Survey Group 1 - Support | Receives a vignette with partner support component before answering AA-Med response items. |
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| Survey Group 2 - Control | Receives a vignette without partner support component before answering AA-Med response items. |
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| Recruitment Group 1 - Casual | Recruited by staff wearing casual attire. |
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| Recruitment Group 2 - Formal | Recruited by staff wearing formal (clinical) attire |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Partner support | Behavioral | The intervention group's survey vignette will include a component of partner support which serves as the key behavioral manipulation tested for this study's primary outcome. |
| Measure | Description | Time Frame |
|---|---|---|
| AA-Med score | Ambiguity aversion score difference between two survey groups; AA-Med contains 6 response items, each scored from 1 to 4 (1=disagree completely; 4=agree completely) | 1 time measurement immediately after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Recruitment rate | Recruitment success rate (fully participated/ approached) difference between two recruitment attire groups | 1 time measurement immediately after intervention |
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Inclusion Criteria:
Exclusion Criteria:
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Recruitment will occur in the Butha Buthe district hospital and health centers in the Butha Buthe district.
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| Name | Affiliation | Role |
|---|---|---|
| Grace H Yoon, MSc | University Hospital Basel, University of Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Butha Buthe Government Hospital | Butha-Buthe | Lesotho |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19731127 | Background | Han PK, Reeve BB, Moser RP, Klein WM. Aversion to ambiguity regarding medical tests and treatments: measurement, prevalence, and relationship to sociodemographic factors. J Health Commun. 2009 Sep;14(6):556-72. doi: 10.1080/10810730903089630. | |
| 41862952 | Derived | Yoon GH, Stoffel S, Aghlmandi S, Lesaoana N, Mahlatsi P, Chakela M, Belus JM, Briel M. Effect of different recruiter attire on trial participation in Lesotho: a randomized study within a trial. Trials. 2026 Mar 20;27(1):290. doi: 10.1186/s13063-026-09638-y. |
| Label | URL |
|---|---|
| OSF project page | View source |
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Data obtained through this study may be provided to qualified researchers with academic interest. Data shared will be completely anonymized. Study components, aggregate data and results will be disseminated on OSF. Any additional data sharing is subject to approval of the request and execution of all applicable agreements (i.e. a material transfer agreement).
Starting six months after completion of data collection for up to 24 months thereafter.
Independent researchers with academic interest.
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| Formal recruiter attire | Behavioral | The SWAT will separately test recruitment rates - as measured by rate of survey completion divided by total number of individuals approached - based on how the recruiters are dressed. FORMAL dress code of the recruiter is the intervention in this case, defined as clinical attire alluding to some clinical authority. |
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| Without Partner support | Behavioral | The intervention group's survey vignette will NOT include a component of partner support which serves as the key behavioral manipulation tested for this study's primary outcome. |
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| Casual recruiter attire | Behavioral | The SWAT will separately test recruitment rates - as measured by rate of survey completion divided by total number of individuals approached - based on how the recruiters are dressed. CASUAL dress code of the recruiter is the intervention in this case. |
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| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D010342 | Patient Acceptance of Health Care |
| D003258 | Consumer Behavior |
| D012919 | Social Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D000074822 | Treatment Adherence and Compliance |
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