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| Name | Class |
|---|---|
| Shanghai Jiao Tong University School of Medicine | OTHER |
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Enhanced recovery after surgery (ERAS) is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a patient-focused, multidisciplinary, and multimodal approach. Alleviating the injury and stress caused by surgery or disease is the core principle of ERAS, which has been shown to reduce complication rates after surgery, promote patient recovery, decrease hospital length of stay and reduce costs. ERAS has been widely applied in many surgical perioperative fields, and it has achieved remarkable effects. However, there are few applications of ERAS in neurosurgery, especially in clinical trials of neurocritical care patients.
Therefore, the investigators attempt to conduct the study of ERAS in neurosurgical intensive patients using a series of optimized perioperative managements that have been verified to be effective by evidence-based medicine, and to evaluate the safety and effectiveness of ERAS in neurocritical care. The aim of this study is to explore the most suitable ERAS protocols to accelerate the postoperative rehabilitation process of neurocritical care patients, and to provide more evidence-based medicine for the effectiveness and safety of ERAS in neurosurgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Enhanced recovery after surgery | Experimental | The technologies, processes and measures of enhanced recovery after surgery were applied. |
|
| Conventional therapy | Active Comparator | Conventional therapy were applied. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Enhanced recovery after surgery | Procedure | The technologies, processes and measures of enhanced recovery after surgery focus on the following aspects:
|
| Measure | Description | Time Frame |
|---|---|---|
| Clinical prognosis | Glasgow Outcome Scale score (1 = death; 2 = persistent vegetative state; 3 = severe disability; 4 = moderate disability; 5 = good but not necessarily complete recovery; unfavorable outcome was defined as score of ≤3, and favorable outcome was defined as a score of >3) | One month, three and six months after injury or attack |
| Neurological function assessment | Modified Rankin scale score (0 = no symptoms; 1 = no significant disability; 2 = slight disability; 3 = moderate disability; 4 = moderately severe disability; 5 = severe disability; 6 = dead; favorable outcome was defined as score of 0-2, and unfavorable outcome was defined as score of 3-6) | One month, three and six months after injury or attack |
| Measure | Description | Time Frame |
|---|---|---|
| Neuroimaging evaluation | Computer tomography or magnetic resonance imaging | One week, two weeks after surgery; one month, three and six months after injury or attack |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hao Chen, M.D., Ph.D. | Contact | 8602164369181 | 8405 | hao.chen@shsmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Hao Chen, M.D., Ph.D. | Shanghai 6th Peoples' Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai 6th People's Hospital | Recruiting | Shanghai | 200233 | China |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D002561 | Cerebrovascular Disorders |
| D008224 | Lymphoma, Follicular |
| D003128 | Coma |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000080482 | Enhanced Recovery After Surgery |
| ID | Term |
|---|---|
| D019990 | Perioperative Care |
| D013514 | Surgical Procedures, Operative |
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|
| Conventional therapy | Procedure | Conventional therapy in neurocritical care. |
|
| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D008228 | Lymphoma, Non-Hodgkin |
| D008223 | Lymphoma |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D014474 | Unconsciousness |
| D003244 | Consciousness Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |