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| Name | Class |
|---|---|
| Region Stockholm | OTHER_GOV |
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The Stockholm CREAtinine Measurements (SCREAM) project is a healthcare utilization cohort including, at present, all adult residents in Stockholm between 2006 and 2021. The region of Stockholm had a population of 2.3 million citizens in 2021and provides universal healthcare with a single unified health-system. Administrative databases with complete information on socidemographic data, healthcare use, diagnoses and therapeutic/surgical procedures, and vital status were enriched with performed laboratory tests, dispensed prescriptions at Swedish pharmacies and validated kidney replacement therapy endpoints. Registries were linked and de-identified by the Swedish National Board of Welfare and are considered to have no or minimal loss to follow-up. Because the study utilized de-identified data, it was deemed not to require informed consent and was approved by the regional ethical review boards and the Swedish National Board of Welfare.
For detailed description of available data and linked registers please consult:
Please consult cohort description in:
https://pubmed.ncbi.nlm.nih.gov/35028991/ https://pubmed.ncbi.nlm.nih.gov/26798472/
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Initiation of specific medications | Drug | multiple therapies studied within this database |
| |
| Undertaking of specific procedures | Procedure | multiple procedures/surgeries studied within this database | ||
| Abnormalities in specific laboratory tests | Diagnostic Test | multiple abnormalities in laboratory values (i.e. CRP, cholesterol, eGFR, potassium) studied within this database |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse health events by levels of kidney function | multiple outcomes evaluated such as cardiovascular events, fractures, dementia, cancer, etc, all of them based on claims data and/or laboratory data | 2006-2021 |
| Safety and efficacy of medications by levels of kidney function | multiple outcomes evaluated depending on the treatments of interest, all of them based on claims data and/or laboratory data | 2006-2021 |
| Effect of medications or conditions on kidney function decline | Evaluation of changes in kidney function over time upon occurrence of a certain condition (i.e., heart failure or covid19 infection) or initiation of a specific medication | 2006-2021 |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse health events associated to laboratory abnormalities | Same as primary objectives but for other laboratory abnormalities different from kidney function measures | 2006-2021 |
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Inclusion Criteria:
For both cohorts:
Be a resident of Stockholm during 2006-2021, of all ages
For the primary cohort:
To have undertaken at least one test of serum creatinine or albuminuria during 2006-2021. If this condition is met, we will then extract a broad range of laboratory tests
For the secondary cohort:
Anyone not undertaking a test of serum creatinine or albuminuria will conform the secondary cohort. In this cohort we will not extract any other laboratory test, but will obtain the rest of healthcare information
Exclusion criteria:
None
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Stockholm residents with/without ever testing for creatinine or albumuninuria
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| Name | Affiliation | Role |
|---|---|---|
| Juan J Carrero, Prof | Karolinska Institutet | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40512561 | Derived | Russel WA, Fu EL, Bosi A, Caldinelli A, Inker LA, Chang AR, Levey AS, Carrero JJ. Obesity, Underweight, and Accuracy of eGFR Using Cystatin C and Creatinine in a Northern European Population. J Am Soc Nephrol. 2025 Nov 1;36(11):2177-2189. doi: 10.1681/ASN.0000000760. Epub 2025 Jun 13. |
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Possibility to share data for collaborative academic research purposes that comply with institutional, national and international ethic principles and legislation on data sharing, access and investigation
For the time required to perform the collaborative project
Primarily by welcoming researchers to analyse the data physically in Stockholm. Exceptionally by opening secure VDI connections to work under our online servers
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| D058186 | Acute Kidney Injury |
| D003920 | Diabetes Mellitus |
| D002318 | Cardiovascular Diseases |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D014652 | Vascular Diseases |