Behavioral Exercise Training to Reduce Cardiovascular Disease Risk

Behavioral Exercise Training to Reduce Cardiovascular Disease Risk in Men Undergoing Androgen Deprivation Therapy (EXTRA-PC)

To test the preliminary effectiveness of a home-based exercise training (ET) intervention to improve exercise capacity (VO2 peak & 6-minute walk distance [6MWD]) among prostate cancer (PC) patients compared to controls receiving healthy living education (HLE) at 12 weeks.

Inclusion Criteria:

• Be diagnosed with stage II/III/IV prostate cancer
• Be currently undergoing treatment with ADT (intermittent or prolonged)
• Have completed local curative-intent treatment, including prostatectomy or definitive radiation;
• Be >40 years of age up to 85;
• Be willing to sign an informed consent with HIPAA authorization form;
• Not have any hearing or sight impairments that result in the inability to use the telephone or hear normal conversation;
• Must be able to join an intervention group by personal computer, smartphone or telephone call and should agree to recording of an interview;
• Be without any serious medical condition that precludes safe participation in an exercise program;
• Speak English

Exclusion Criteria:

• Be unable to undergo MRI (i.e., ferromagnetic materials in body, inability to lie flat, claustrophobia);
• Have contraindications to exercise testing;
• Have pre-existing overt cardiovascular disease/heart failure;
• Active illness/infection;
• Hemoglobin < 7.0 grams/dL
• Platelet count < 10 x 109/L