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| Name | Class |
|---|---|
| Korea Health Industry Development Institute | OTHER_GOV |
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The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver transplantation (LT) for treating hepatocellular carcinoma.
The main question[s] it aims to answer are:
Researchers will compare the NSBB group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NSBB group | The NSBB group was defined as those who received NSBBs for at least 30 consecutive days within the 3 months prior to LT. |
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| Control group | Those who did not meet the above criteria were classified as the control group. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use | Drug | Non-selective blocker including Propranolol, Carvedilol PO was prescribed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Kaplan-Meier survival analysis of HCC recurrence at 5-year follow-up | HCC recurrence, which was diagnosed based on pathological or radiographic evidence of new lesions consistent with HCC, and recurrence-free survival was collected and compared using Kaplan-Meier survival analysis. | Baseline and 5-year follow-up |
| Multivariate Cox regression analysis of HCC recurrence at 5-year follow-up | Multivariate Cox regression analysis was performed to identify the risk factors for HCC recurrence. | Baseline and 5-year follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Kaplan-Meier survival analysis of overall survival at 5-year follow-up | Overall survival was collected and compared using Kaplan-Meier survival analysis. | Baseline and 5-year follow-up |
| Multivariate Cox regression analysis of overall survival at 5-year follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent liver transplantation at Asan Medical Center between Jan. 2008 - May 2022. Asan Medical Center is a tertiary, teaching hospital of the University of Ulsan College of Medicine, located in Seoul, South Korea.
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| Name | Affiliation | Role |
|---|---|---|
| Jun-Gol Song, MD, PhD | Department of Anesthesiology and Pain Medicine, Asan Medical Center | Study Chair |
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Multivariate Cox regression analysis was performed to identify the risk factors for overall mortality. |
| Baseline and 5-year follow-up |
| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
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