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Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stimulus magnitude | Experimental | Differing levels of tactile stimulus will be applied |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tactile stimulation | Behavioral | Tactile stimuli of differing magnitudes will be applied |
|
| Measure | Description | Time Frame |
|---|---|---|
| Conscious detection threshold | The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N. | 30 minutes during the first session of a one session protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Brain activation | The magnitude and regions of brain activated in response to differing levels of force stimuli will be captured using fMRI. The % signal change in the brain will be used to define the brain activation in response to each force stimulus level. | 60 minutes during the first session of a one session protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Peripheral nerve function | Electrotactile stimuli will be applied to a finger, with the current (A) changing in magnitude. We will measure the level to which the peripheral nerve is activated using surface electrodes, which identify changes in voltage along the nerve. | 30 minutes during the first session of a one session evaluation protocol |
Inclusion Criteria:
-right-hand dominance for participants who are neurotypical
For Aim 1:
-age range of 18-23
For Aim 2:
Exclusion Criteria:
For Aim 2:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Netta Gurari, PhD | Contact | 540-231-3073 | gurari@vt.edu |
| Name | Affiliation | Role |
|---|---|---|
| Netta Gurari, PhD | Virginia Polytechnic Institute and State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Tech | Recruiting | Blacksburg | Virginia | 24061 | United States |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |