Randomized controlled trial

Targeted patients who come to receive treatment for osteoarthritis that meets the research indications will be assigned to a random group by the box of 4 randomization method, with a sequence that is randomly generated by a computer. The groups are divided into two groups:

Group 1: Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen

Group 2: Control patients will take placebo

Primary outcome : Pain level

Inclusion Criteria:

• Age: 50-80 years old
• Medial compartment knee osteoarthritis
• Kellgren and Lawrence classification stage 2 -3
• Able to walk without walking aid

Exclusion Criteria:

• History of knee surgery on the study side
• History of intra-articular steroid injection within 6 months prior to study entry
• Systemic arthritis conditions
• Degenerative neurological and muscular conditions in the lower extremities
• Chronic kidney disease with CrCl < 30 ml/min (glomerular filtration rate <60 mL/min/1.73 m2)

Data will become available and for 1 year after publication.

Open Science Framework (OSF)