Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee

Efficacy of Hydrolyzed Collagen and Undenatured Collagen Type II in Alleviating Pain in Patients With Knee Osteoarthritis

Randomized controlled trial

Targeted patients who come to receive treatment for osteoarthritis that meets the research indications will be assigned to a random group by the box of 4 randomization method, with a sequence that is randomly generated by a computer. The groups are divided into two groups:

Group 1: Patients who have taken 480 mg of hydrolyzed collagen and 20 mg of undenatured type II collagen

Group 2: Control patients will take placebo

Primary outcome : Pain level

Inclusion Criteria:

• Age: 50-80 years old
• Medial compartment knee osteoarthritis
• Kellgren and Lawrence classification stage 2 -3
• Able to walk without walking aid

Exclusion Criteria:

• History of knee surgery on the study side
• History of intra-articular steroid injection within 6 months prior to study entry
• Systemic arthritis conditions
• Degenerative neurological and muscular conditions in the lower extremities
• Chronic kidney disease with CrCl < 30 ml/min (glomerular filtration rate <60 mL/min/1.73 m2)