Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Mango Board | OTHER |
Not provided
Not provided
Not provided
Not provided
The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years
The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30. To accomplish these objectives, a randomized controlled, parallel design study is proposed with two groups consuming their habitual diet, but with one (Mango group) receiving 1.5 servings of mango/day and the other (Control group) abstaining from eating any mango for the duration of the study.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mango Group | Active Comparator | Participants in the Mango group will consume 1.5 cups of mangos for 12 weeks |
|
| control group | No Intervention | The control group will receive no dietary intervention. they will follow usual diet and abstain from eating mangos |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mango group | Dietary Supplement | Participants will consume 1.5 cups of mangos per day for 12 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in lymphocyte populations | Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells | baseline to 12 weeks |
| Changes in Lymphocyte activity | The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA) | baseline to 12 weeks |
| Changes in cytokine production | The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA) | baseline to 12 weeks |
| Changes in serum inflammatory cytokine concentration | changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin, | baseline to 12 weeks |
| changes from baseline in global cognitive composite score | The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test | baseline to 12 weeks |
| Change in serum brain-derived neurotrophic factor (pg/mL) | changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sujatha Rajaram, PhD | Contact | 909-558-4300 | 47228 | srajaram@llu.edu |
| Amandeep Wright, MPH | Contact | 909-558-4300 | 47169 | amawright@llu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sujatha Rajaram, PhD | Loma Linda University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Loma Linda University School of Public Health | Loma Linda | California | 92350 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
this will be a12 week, parallel study , free living with college going young adults aged 18-30 years
Not provided
Not provided
The investigator and outcome assessor will not be aware of which participant is in which arm
| baseline to 12 weeks |