Inadequate medication adherence (MA) in chronic conditions, including cardiovascular prevention, represents an important risk factor. The use of new IT technologies in this setting is supposed to be useful to improve patients' adherence, but currently available solutions have significant limitations, including lack of personalization and reliance on expensive ad hoc systems.

This interdisciplinary project aims to verify the hypothesis that in patients on chronic antihypertensive treatment MA can be improved through the implementation of a novel digital health solution for MA monitoring and support, based on inexpensive and user-friendly, commercially available technology (voice assistant), connected with web interface for the physician. The intervention will be personalized based on the creation of Personas, intended as multidisciplinary-based representations of different user types. This approach will be tested in a randomized clinical trial.

Inclusion Criteria:

• Adult (>18 years old) patients
• History of essential hypertension
• Treatment with at least one antihypertensive drug for which dedicated plasma essay is available
• wireless internet connection available at patients' home
• stable clinical conditions
• written informed consent

Exclusion Criteria:

• insufficient technological literacy to manage vocal assistant
• dementia or significant psychiatric disorders
• conditions significantly limiting vocal communication (deafness, significant speech disorders, poor knowledge of Italian language)
• pregnancy or breastfeeding
• active cancer (except basal cell skin carcinoma)
• upper limb amputation