Association Between EEG Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation

Evaluation of the Association Between Electroencephalographic Changes and Hormonal Response to Tracheal Intubation and Surgical Stimulation in Abdominal Surgery: a Prospective Observational Study

This study aims to prospectively evaluate the relationship between changes in EEG and hormonal responses induced by endotracheal intubation and surgical incision following general anesthesia.

This study aims to investigate the relationship between changes in EEG patterns and stress hormone levels in patients undergoing open abdominal surgery under general anesthesia when subjected to endotracheal intubation and surgical incision stimuli.

Hormone measurements (cortisol, ACTH) are taken at four time points: before endotracheal intubation (T1), one minute after intubation (T2), and one minute after surgical incision (T3). The investigators evaluate the correlation between hormone levels (cortisol, ACTH) and EEG band power changes (alpha, beta, delta) before and after endotracheal intubation and surgical incision.

Inclusion Criteria:

• 1) Patients scheduled to undergo open abdominal surgery under general anesthesia with endotracheal intubation.
• 2) Patients requiring invasive blood pressure monitoring during surgery

Exclusion Criteria:

• 1) Patients transferred to the intensive care unit after surgery
• 2) Surgery duration of less than one hour
• 3) Patients with neurological underlying conditions
• 4) Patients on chronic use of psychotropic medications and opioid drugs
• 5) Emergency surgery