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The goal of this study is to establish a diagnostic accuracy of an immediate pressor response to oral salt (IPROS) to identify salt sensitivity of blood pressure (SSBP)
Participants are given dietary salt and their BP is measured every 10 minutes for 2 hours. IPROS is diagnosed with significant mean arterial pressure increase
For SSBP, participants are put on high salt diet for a week and monitored and low salt week. The Mean arterial pressure difference between high salt and low salt is used to diagnose SSBP
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| intervention | Experimental | intervention given |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| salt | Other | After ≥8 hr overnight fasting, participants will be required to ingest 780 mg of sodium (2 g salt) and BP measured every 10 minutes for 2 hours to determine IPROS. For SSBP, Participants are put on low salt (50 mmol Na/day) followed by seven days of high salt diet (250 mmol Na/day). Participants' mean arterial pressure (MAP) difference between low- and high-salt diet will be used to define salt sensitivity (MAP≥8 mmHg) and salt resistance (MAP≤5 mmHg). |
| Measure | Description | Time Frame |
|---|---|---|
| SSBP | Salt sensitivity status | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| IPROS | Immediate pressor response | 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sepiso K Masenga, PhD | Contact | +260977674774 | sepisomasenga@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Livingstone University Teaching Hospital | Not yet recruiting | Livingstone | Southern Province | 10101 | Zambia |
Data set and manuscripts published
2025
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D012492 | Salts |
| ID | Term |
|---|---|
| D007287 | Inorganic Chemicals |
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|
| Kanyama General Hospital | Recruiting | Lusaka | 10101 | Zambia |
|