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| Name | Class |
|---|---|
| Ministry of Education and Science,Poland | UNKNOWN |
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The impact of a proprietary training program in normobaric hypoxia on changes in bone turnover markers as well as carbohydrate and lipid metabolism in premenopausal women falls within the realm of physical culture for an active and healthy society. Within this context, the implementation of a project is supported aiming to:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | The control group will not undergo the training program. | |
| Training in normobaric hypoxia | Experimental | Training performed under normobaric hypoxia (Week I-1600m above sea level; Week II-1800m above sea level; Week III-2200m above sea level; Week IV-2600m above sea level) and thermoneutral conditions (21°C) and constant humidity (40%). |
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| Training in normoxia | Experimental | Description: Training performed in normoxia (223 m above sea level) and thermoneutral conditions (21°C) and constant humidity (40%). |
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| Passive exposure to normobaric hypoxia | Experimental | Passive exposure to normobaric hypoxia conditions (Week I -1600m above sea level; Week II -1800m above sea level; Week III -2200m above sea level; Week IV-2600m above sea level) and thermoneutral conditions (21°C) and constant humidity (40%). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise and environmental conditions | Other | Participants will perform endurance-strength training for 4 weeks in a variety of environmental conditions. Somatic indices and quantitative indicators of bone mass (bone mineral density) will be measured both before and after the training period. Before the first training day and the day after the last training day, blood will be drawn for biochemical analysis. |
| Measure | Description | Time Frame |
|---|---|---|
| Blood analysis- part 1 | Bone turnover markers: bone-specific alkaline phosphatase (ng/ml), osteocalcin (ng/ml), N-terminal telopeptide of type I collagen (ng/ml), osteoprotegerin (ng/ml), 25-hydroxyvitamin D3 metabolite (ng/ml). | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 2 | Hormones of lipid metabolism: adiponectin (μg/mL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 3 | Hormones of lipid metabolism: lipid profile (mg/dL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 4 | Hormones of lipid metabolism: lipoprotein atherogenicity index (no unit) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 5 | Hormones of carbohydrate metabolism: glucose (mg/dL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 6 | Hormones of carbohydrate metabolism: insulin (IU/mL), leptin (IU/mL), ghrelin (IU/mL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna Radoń, MSc | Contact | +45126831142 | anna.radon@awf.krakow.pl | |
| Małgorzata Bagińska, MSc | Contact | malgorzata.baginska@doctoral.awf.krakow.pl |
| Name | Affiliation | Role |
|---|---|---|
| Małgorzata Bagińska, MSc | Student of Doctoral studies, University of Physical Education in Kraków, Poland | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University School of Physical Education in Cracow | Not yet recruiting | Krakow | 31-571 | Poland |
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| exercise and environmental conditions | Other | Passive exposure to normobaric hypoxia conditions. No training intervention. There will be a measurement of selected somatic indices and a quantitative measurement of bone mass indices (bone mineral density). A blood draw for biochemical analysis will be performed. |
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| Blood analysis- part 7 | Thyroid hormones: Thyroid Stimulating Hormone (IU/L) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 8 | Vitamins: Vitamin D (ng/mL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 9 | Plasma volume changes (ml/kg) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 10 | Rheology: viscosity (Pa·s), viscoelasticity (Pa·s) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 11 | Rheology: shear rate (s-¹) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 12 | Rheology: shear stress (Pa), elastic modulus (Pa) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 13 | Blood biochemistry: erythrocytes (million/μL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 14 | Blood biochemistry: leukocytes (thousand/μL), platelets (thousand/μL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 15 | Blood biochemistry: hemoglobin (g/dL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 16 | Blood biochemistry: hematocrit (%), red cell distribution width (%) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 17 | Blood biochemistry: mean corpuscular volume (femtoliter) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 18 | Blood biochemistry: mean corpuscular hemoglobin (picogram) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 19 | Blood biochemistry: mean corpuscular hemoglobin concentration (g/dL), albumin (g/dL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 20 | Blood biochemistry: creatinine (mg/dL), bilirubin (mg/dL), blood urea nitrogen (mg/dL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 21 | Blood biochemistry: erythrocyte sedimentation rate (mm/h) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 22 | Blood biochemistry: alanine aminotransferase (U/L), aspartate aminotransferase (U/L) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Blood analysis- part 23 | Blood biochemistry: ferritin (ng/mL) | Before (10 minutes) and after (3 minutes) the first and last training.The training will last 4 weeks and will consist of 12 workouts |
| Bone mass- part 1 | To identify quantitative indicators of bone mass, a densitometric study will be performed using dual energy X-ray absorptiometry (DXA). Selected quantitative indicators of bone mass will be measured: bone mineral density (g/cm^2). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Bone mass- part 2 | To identify quantitative indicators of bone mass, a densitometric study will be performed using dual energy X-ray absorptiometry (DXA). Selected quantitative indicators of bone mass will be measured: T-score (no unit). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Bone mass- part 3 | To identify quantitative indicators of bone mass, a densitometric study will be performed using dual energy X-ray absorptiometry (DXA). Selected quantitative indicators of bone mass will be measured: Z-score (no unit). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Bone mass- part 4 | To identify quantitative indicators of bone mass, a densitometric study will be performed using dual energy X-ray absorptiometry (DXA). Selected quantitative indicators of bone mass will be measured: relative skeletal-muscular index (kg/m^2). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Somatic indicators- part 1 | A densitometry study using dual energy X-ray absorptiometry (DXA) will be conducted to determine body composition: lean body mass (kg). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Somatic indicators- part 2 | A densitometry study using dual energy X-ray absorptiometry (DXA) will be conducted to determine body composition: percentage of body fat (%). | 1 day before and 1 day after the training program. Training will last 4 weeks. |
| Somatic indicators- part 3 | A densitometry study using dual energy X-ray absorptiometry (DXA) will be conducted to determine body composition: fat mass (kg). | 1 day before and 1 day after the training program. Training will last 4 weeks |
| University School of Physical Education in Cracow | Recruiting | Krakow | 31-571 | Poland |
|
| ID | Term |
|---|---|
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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