EEG-guided Propofol Sedation Versus Standard Care for Oesophagogastroduodenoscopy and Colonoscopy in Children: A Randomised Controlled Trial to Improve Sedation Safety and Experience
EEG-guided Propofol Sedation Versus Standard Care for Oesophagogastroduodenoscopy and Colonoscopy in Children: A Randomised Controlled Trial to Improve Sedation Safety and Experience
The goal of this clinical trial is to compare electroencephalogram (EEG) guided propofol sedation versus standard care in paediatric patients aged 6-16 undergoing oesophagogastroduodenoscopy and colonoscopy. The main questions it aims to answer are whether EEG guided propofol sedation will result in:
BACKGROUND AND RATIONALE Oesophagogastroduodenoscopy (OGD) and colonoscopy in children are often performed under deep sedation with propofol. Titration of propofol dosage is based solely on cardiorespiratory parameters obtained from standard ASA monitoring. However, this method of propofol titration does not allow visualisation of the patients' brain response and often leads to under- or over-sedation. Under-sedation can lead to undesirable intra-operative movement and potential awareness, while over-sedation is associated with complications such as apnea, hypoxaemia, hypotension, prolonged time to awakening and delay in PACU discharge.(1,2)
Patients are often over-sedated during propofol anaesthesia. A study in adults undergoing colonoscopy using electroencephalography (EEG) monitoring showed that although providers planned for moderate-to-deep sedation, retrospective review of the EEG revealed that many patients were under general anesthesia, often with burst suppression (3) EEG burst suppression has been linked to postoperative deliriumin the elderly (4), and anesthesia titration to minimize burst suppression may decrease the incidence of postoperative delirium. Likewise, over-sedation and EEG isoelectric events are common in children undergoing propofol anesthesia with dosing based solely on population pharmacokinetics and patient haemodynamics. (5)
It was recently proposed that EEG monitoring and guidance during anaesthesia and sedation in children allows direct visualisation of each patient's brain response and complements current standard monitoring to enhance patient safety and experience.(2) EEG-guidance has been shown to reduce sevoflurane requirements in children undergoing general anaesthesia. (9) In particular, the EEG spectrogram, also called density spectral array (DSA), allows easy visualisation of the interactions between brain response, hemodynamic response, and changing procedural stimulation in real time, thus facilitating more precise and nuanced titration of anaesthetic agents. (2)
Processed EEG (pEEG) such as the bispectral index (BIS), Narcotrend index (NI) and patient state index (PSI) are dimensionless numbers derived from the EEG using manufacturers' algorithms to quantify anaesthetic depth (6). However, given the lack of clarity on how different pEEG numbers are computed and how they relate to fundamental neurophysiological properties of the developing brain, it is important to interpret the pEEG number in relation to the raw EEG waveform and spectrogram.
Only two small studies have compared EEG-guided propofol anaesthesia with standard care in children, both using the Narcotrend Index (NI). NI-guidance was shown to result in slightly faster recovery and lower drug consumption.(7)(8). To date, no study has utilised the spectrogram together with the pEEG number to guide anaesthesia. The investigators aim to compare EEG-guidance using Sedline EEG and spectrogram, in addition to the PSI, with standard care in children undergoing propofol TIVA for OGD and colonoscopy. Better visualisation of the brain response using the spectrogram may lead to more precise titration of propofol doses, lower propofol consumption and greater reduction in wake up time.
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HYPOTHESIS AND OBJECTIVES The primary hypothesis is that in children aged 6-16, personalised EEG-guided anaesthesia care using the Sedline, (based on the raw EEG, density spectral array, in addition to the patient state index (PSI)), will result in faster wake up (defined as time from end of procedure to time of first eye opening) after propofol sedation for OGD and colonoscopy by 8 minutes.
Our secondary hypotheses are that in children aged 6 to 16, personalised EEG-guided anaesthesia care using the Masimo Sedline, (based on the unprocessed EEG, density spectral array, in addition to the patient state index (PSI)) leads to:
Our primary aim is to determine if personalised EEG-guided anaesthesia care using the Sedline reduces the time to wake up after propofol sedation for oesophagogastroduodenoscopy (OGD) and colonoscopy.
Our secondary aims are to determine if personalised EEG-guided anaesthesia care reduces
Inclusion Criteria
Subjects must meet all of the inclusion criteria to participate in this study. Inclusion Criteria:
Exclusion Criteria
Subjects meeting any of the exclusion criteria at baseline will be excluded from participation in the study. Exclusion Criteria:
STUDY DESIGN AND PROCEDURES/METHODOLOGY This is a single centre randomized controlled study of 50 children aged 6-16 years of age undergoing oesophagogastroduodenoscopy or colonoscopy under intravenous anaesthesia with propofol.
Following institutional ethics approval and written informed consent, children aged 6 to 16 receiving propofol sedation for colonoscopy lasting will be randomised in a 1:1 ratio to either:
Group 1: EEG Monitoring: EEG sensor placed with the EEG monitored. Propofol titrated according to the raw EEG and spectrogram, aiming to maintain sedation (alpha oscillations +/- slow oscillations) and preventing burst suppression, keeping the PSI greater than 25 where possible.
Group 2: Standard Care: EEG sensor placed with the output concealed. The anaesthesia team is blinded to the EEG data. Propofol is titrated according to routine standard care.
The EEG sensor will be placed over the forehead prior to induction of anaesthesia, and removed once the patient is awake at the conclusion of general anaesthesia. Routine monitors including ECG, pulse oximetry and non-invasive blood pressure will be placed and the patients managed according to standard care.
The pharynx will be tropicalized with 10% Xylocaine spray prior to insertion of the endoscope.
Fentanyl 0.5 mcg/kg and lignocaine 0.5mg/kg will be given prior to induction.
Propofol target controlled infusion (TCI) - Paedfusor model, will be used. The induction dose will be Cp 4.0mcg/ml and then titrated to patient response with (group 1) or without (group 2) EEG guidance.
Intra-operatively, the details of the anaesthetic, including the duration of sedation, TCI dosage at different pre-specified time points and cumulative propofol dosage, will be recorded. EEG characteristics during insertion of scope, maintenance, removal of scope and emergence will be noted. Any undesirable intraoperative patient movements, adverse events including apnea, hypoventilation requiring bag mask ventilation, laryngospasm, hypotension will also be recorded.
In the PACU, the time to wake up, time to PACU discharge, and the incidence and severity of emergence delirium will be recorded. The EEG information will be downloaded and anonymised for analysis. The incidence and duration of burst suppression, spectral edge frequency; alpha power and frequency; slow power and frequency will be recorded.
The investigators will compare the:
Inclusion Criteria:
Exclusion Criteria: