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The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
Presepsin is a plasmatic cleaved fragment of CD14. CD14 is a toll like receptor who has the role to identify certain lipopolysaccharides on the surface of bacteria (aerobes and anaerobes), thus promoting an inflammatory response.
A study of 153 patients with liver cirrhosis published by a team of investigators from Iasi, Romania, has proven an useful role of plasma presepsin in early diagnosis of infections in patients in acute on chronic liver failure.
In addition, plasma presepsin has been proposed as an independent predictor of mortality in patients with decompensated liver cirrhosis, without concomitant bacterial infections.
Question to be answered by this study The investigators aim to evaluate the predictive role of ascites presepsin in patients with chronic liver failure.
Hypothesis Presepsin levels in ascites may have a prognostic role in patients with ascites and chronic liver failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with chronic liver failure and ascites |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Determination of presepsin levels in ascites | Diagnostic Test | A diagnostic paracentesis will be performed and presepsin level will be determined in ascites. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality at 6 months | Number of who deceased during admission or during the 180 days after admission divided by the number of patients who were admitted. An analysis will be done to see if the presepsin levels are predictive for this event. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Spontaneous bacterial peritonitis (SBP) rate | The number of patients diagnosed with SBP during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. | 6 months |
| Hepatic encephalopathy rate |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients admitted with chronic liver failure and ascites. A diagnostic paracentesis will be performed at the day of admission.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mihai Ciocirlan | Contact | 0040722322625 | ciocirlanm@yahho.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| "Agrippa Ionescu" Hospital | Recruiting | Bucharest | Romania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36143057 | Background | Igna R, Girleanu I, Cojocariu C, Huiban L, Muzica C, Singeap AM, Sfarti C, Chiriac S, Petrea OC, Zenovia S, Nastasa R, Cuciureanu T, Stafie R, Stratina E, Rotaru A, Stanciu C, Blaj M, Trifan A. The Role of Presepsin and Procalcitonin in Early Diagnosis of Bacterial Infections in Cirrhotic Patients with Acute-on-Chronic Liver Failure. J Clin Med. 2022 Sep 15;11(18):5410. doi: 10.3390/jcm11185410. | |
| 33484772 |
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| ID | Term |
|---|---|
| D017093 | Liver Failure |
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
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Ascites, peripheral blood
Number of patients diagnosed with hepatic encephalopathy during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. |
| 6 months |
| Any infection rate | The number of patients diagnosed with any infection during admission divided by the total number of patients. An analysis will be done to see if the presepsin levels are predictive for this event. | 6 months |
| Background |
| Ferrarese A, Plebani M, Frigo AC, Burra P, Senzolo M. Presepsin as a biomarker of inflammation and prognosis in decompensated liver disease. J Hepatol. 2021 Jul;75(1):232-234. doi: 10.1016/j.jhep.2021.01.016. Epub 2021 Jan 21. No abstract available. |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |