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| Name | Class |
|---|---|
| United States Department of Agriculture (USDA) | FED |
| The California Walnut Commission | UNKNOWN |
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The proposed research is a randomized crossover trial designed to assess changes in postprandial cognitive function and the gut-brain axis in adults with subjective cognitive complaints who consume 1 study snack per day for 1 week.
Study objective including
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Walnuts | Experimental | consumption of walnuts every day |
|
| White chocolate-style bar | Experimental | consumption of a white chocolate-style bar every day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Walnuts | Other | 56g of walnuts consumed each day for 7 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function measured using the National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function Cognitive Battery (NIHTB-CB) | To determine the impact of consuming the study dietary fats as part of a high fat meal on postprandial cognitive function | Week 0 and Week 5 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive function measured using the National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function Cognitive Battery (NIHTB-CB) | To assess changes in cognitive function after consuming 1 serving of the dietary fats every day for 1 week | Week 0, Week 1, Week 5 and Week 6 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in postprandial energy metabolism | To evaluate the effect of dietary fats on postprandial indirect calorimetry (kilocalories) | Week 0 and Week 5 |
| Changes in postprandial respiratory quotient | To evaluate the effect of dietary fats on postprandial respiratory quotient to identify what fuels (carbohydrate protein or fat) are utilized |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Martha Belury, PhD, RDN | Contact | 614-292-1680 | belury.1@osu.edu | |
| Rachel Cole | Contact | 614-247-8235 | belurylabstudies@osu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Martha Belury, PhD, RDN | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ohio State University | Recruiting | Columbus | Ohio | 43210 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41418290 | Derived | Zarich S, Cole RM, Fairchild K, Spakowicz D, Sparagna G, Madison A, Ni A, Belury MA. Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial. JMIR Res Protoc. 2025 Dec 19;14:e82032. doi: 10.2196/82032. |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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| Simply White Diary-free chocolate bar |
| Other |
68g of the white chocolate style-bar each day for 7 days |
|
| Changes in fecal Microbiota diversity |
To assess changes in microbiota diversity of fecal samples after consuming 1 serving of the dietary fats every day for 1 week |
| Week 0, Week 1, Week 5 and Week 6 |
| Week 0 and Week 5 |
| Changes in postprandial lipids | To evaluate the effect of dietary fats on postprandial lipid panel including total cholesterol, HDL-Cholesterol, LDL-Cholesterol, Triglycerides (mg/dL) | Week 0 and Week 5 |
| Changes in postprandial Tumor necrosis factor levels | To evaluate the effect of dietary fats on postprandial blood Tumor necrosis factor alpha (TNF), a marker of inflammation | Week 0 and Week 5 |
| Changes in postprandial IL-6 | To evaluate the effect of dietary fats on postprandial blood IL-6 a marker of inflammation | Week 0 and Week 5 |
| Changes in postprandial C-Reactive Protein | To evaluate the effect of dietary fats on postprandial blood C-reactive protein, a marker of inflammation | Week 0 and Week 5 |
| Changes in postprandial Soluble intercellular adhesion molecule-1 | To evaluate the effect of dietary fats on postprandial blood Soluble intercellular adhesion molecule-1, a marker of inflammation | Week 0 and Week 5 |
| Changes in cardiolipin species | To determine the impact of dietary fat on peripheral blood mononuclear cell cardiolipin species measured using electrospray ionization-mass spectrometry coupled to high-performance liquid chromatography | Week 0, Week 1, Week 5 and Week 6 |
| Changes in postprandial glucose levels | To determine the impact of dietary fat on postprandial blood glucose levels | Week 0 and Week 5 |
| Changes in postprandial insulin levels | To determine the impact of dietary fat on postprandial blood insulin levels | Week 0 and Week 5 |
| Changes in postprandial cortisol levels | To determine the impact of dietary fat on postprandial salivary cortisol levels | Week 0 and Week 5 |