The goal of this observational study is to learn about the value of multimodal ultrasound in early detection of left ventricular systolic dysfunction in patients with chronic kidney disease(CKD). The main questions it aims to answer are:

1. If first-phase ejection fraction（EF1）could early detect the left ventricular systolic dysfunction in patients with CKD.
2. Whether EF1 can detect left ventricular systolic dysfunction in patients with CKD more sensitively than speckle-tracking echocardiography and myocardial work.

Participants will need to cooperate to do an echocardiography. Researchers will compare healthy volunteers and patients with CKD to see if EF1 could early detect the left ventricular systolic dysfunction.

Inclusion Criteria:

• Patients with chronic kidney disease who are hospitalized in The Fifth Affiliated Hospital of Sun Yat-sen University.
• LVEF≥50%.

Exclusion Criteria:

• Patients with primary hypertension, diabetes and congenital heart disease.
• Patients who are pregnant or lactating.
• Patients with the blurry ultrasound images.

Patients with chronic kidney disease who are hospitalized in The Fifth Affiliated Hospital of Sun Yat-sen University.