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To compare between the efficacy of fascia lata allograft and platelet rich fibrin versus subepithelial connective tissue graft on periodontal phenotype (thickness and width of keratinized tissue, labial bone thickness) around dental implant in upper anterior region.
In order to evaluate the effectiveness of fascia lata allograft, platelet-rich fibrin, and subepithelial connective tissue graft on periodontal phenotype (including the thickness and width of keratinized tissue, as well as the thickness of labial bone) around dental implants in the upper anterior region, the purpose of this study is to compare the three types of grafts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fascia Lata (Study group) | Experimental | It includes eight patients seeking for implant placement in the upper anterior areas and implants will be placed with the application of fascia lata allograft membrane. |
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| PRF (Study group) | Experimental | It includes eight patients seeking for implant placement in the upper anterior area and implants will be placed with the application of PRF. |
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| Connective tissue Graft(Control group) | Active Comparator | It includes eight patients seeking for single implant placement at the upper anterior area and those patients will be received their implants with subepithelial connective tissue graft. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fascia lata membrane | Drug | novel allogenic derived acellular matrix produced from human fascia lata allograft |
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| Measure | Description | Time Frame |
|---|---|---|
| Pink aesthetic score | Pink esthetic score The gingival response to a anterior esthetic evaluation is assessed by the Pink Esthetic Score (PES) from clinical photography | 6 Months |
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Inclusion Criteria:
Exclusion Criteria:
Patients age ranged from 20 to 50
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Elhadidy, Msc | Contact | +201002698979 | ahmed.elhadidyy.93@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Enas elgendy, Prof | Professor of Oral medicine and Periodontology at Kafr Elsheikh University | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34373184 | Background | Moraschini V, Kischinhevsky ICC, Sartoretto SC, Shibli JA, Dias AT, Sacco R, Yates J, Calasans-Maia MD. Is there any biomaterial substitute for peri-implant soft tissue phenotype modification? A network meta-analysis of the appraisal literature. Int J Oral Maxillofac Surg. 2022 Apr;51(4):526-534. doi: 10.1016/j.ijom.2021.07.005. Epub 2021 Aug 7. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Jan 1, 2024 | Jan 12, 2024 | Prot_SAP_000.pdf |
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Patients were classified into three main groups:
Group 1 (Study group) It includes eight patients seeking for implant placement in the upper anterior areas and implants will be placed with the application of fascia lata allograft membrane.
Group 2 (Study group) It includes eight patients seeking for implant placement in the upper anterior area and implants will be placed with the application of PRF.
Group 3 (Control group) It includes eight patients seeking for single implant placement at the upper anterior area and those patients will be received their implants with subepithelial connective tissue graft.
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| Platlet Rich fibrin membrane | Drug | Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRF where autologous platelets and leukocytes are present in a complex fibrin matrix to accelerate the healing of soft and hard tissue |
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| subepithelial connective tissue graft | Drug | The connective tissue is generally taken from the hard palate, although it may be taken from other sites as well, such as the maxillary tuberosity area. |
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