BCAAs, Muscle Protein Synthesis and Glucose Uptake | NCT06218264

Studies
BCAAs, Muscle Protein Synthesis and Glucose Uptake

NCT06218264

Sponsor

Wageningen University

Status

Completed

Last Update Posted

Feb 20, 2026Actual

Enrollment

24Actual

Phase

Not Applicable

Conditions

Healthy

Interventions

Ingestion of an amino acid supplement

Countries

Netherlands

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Feb 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jan 10, 2024Actual

Primary Completion Date

Feb 13, 2026Actual

Completion Date

Feb 13, 2026Actual

First Submitted Date

Jan 11, 2024

First Submission Date that Met QC Criteria

Jan 11, 2024

First Posted Date

Jan 23, 2024Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Feb 18, 2026

Last Update Posted Date

Feb 20, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.

Detailed Description

Twenty-eight healthy, young volunteers will receive a stable isotope tracer infusion (7.5h) combined with repeated blood and muscle sampling, to measure muscle protein synthesis rate in the postabsorptive state following ingestion of a drink containing all amino acids (n=14) or all amino acids except for BCAAs (n=14).

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

24Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
FullAA	Active Comparator	Amino acid drink containing all amino acids	Dietary Supplement: Ingestion of an amino acid supplement
NoBCAA	Active Comparator	Amino acid drink containing all amino acids except for BCAAs.	Dietary Supplement: Ingestion of an amino acid supplement

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Ingestion of an amino acid supplement	Dietary Supplement	Oral intake of a supplement containing amino acids	FullAA NoBCAA

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Postprandial muscle protein synthesis	Muscle protein synthesis rate (FSR) prior to and following ingestion of an amino acid drink	4 hours

Secondary Outcomes

Measure	Description	Time Frame
Forearm muscle glucose uptake	Insulin sensitivity, measured as forearm glucose uptake, prior to and following ingestion of an amino acid drink	7.5 hours
Whole-body insulin sensitivity	Whole-body insulin sensitivity, calculated using a modified Matsuda index

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Aged from 18-35 years
18.5 < Body mass index < 30 kg·m2
Recreationally active (performing non-competitive physical exercise at least one time per week for minimally 30 minutes)

Exclusion Criteria:

Smoking
Diabetes (Type 1, Type 2, or genetic form of diabetes)
Any diagnosed cardiovascular (heart) disease or high blood pressure (≥140 mmHg systolic and/or ≥90 mmHg diastolic)
Chronic use of any prescribed or over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices)
Known allergy to lidocaine
Regular use of dietary protein and/or amino acid supplements (>3 times per week)
Currently involved in a structured progressive resistance training programme (>3 times per week)
A personal or family history of thrombosis (clots), epilepsy, seizures, or schizophrenia.
Any previous motor disorders or disorders in muscle and/or lipid metabolism
Presence of an ulcer in the stomach or gut and/or strong history of indigestion
Known severe kidney problems
Pregnant or breastfeeding
Unable to give consent

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

35 Years

Standard Ages

Adult

Study Population

Not provided

Sampling Method

Not provided

Facility	Status	City	State	ZIP	Country	Contacts
Wageningen University and Research		Wageningen	Gelderland	6708 WD	Netherlands

IPD Sharing Statement Module

Plan to Share IPD

Description

Not provided

Types

Not provided

Time Frame

Not provided

Access Criteria

Not provided

URL

Not provided