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| Name | Class |
|---|---|
| Tianjin Medical University General Hospital | OTHER |
| Gansu Provincial Centre for Disease Control and Prevention | UNKNOWN |
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Current Chinese dietary iodine reference intake (DRIs) standards lack direct data on recommended iodine intake (RNI) in the elderly. The elderly have a high prevalence of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. Identifying the appropriate iodine intake for the elderly to maintain optimal thyroid function to reduce the burden on medical resources is a public health issue requiring high attention. The iodine balance study is an important method for exploring physiological iodine requirements. Few iodine balance studies have been conducted in the elderly. This study aimed to conduct an iodine balance study and provide information on the appropriate iodine intake level for elderly people.
The investigators measured subjects' food and water intake throughout the day using weighing methods, and collected all urine and fecal samples. Food, drinking water, fecal and urine samples were taken to determine iodine concentrations. Each subject was required to participate in two phases of iodine balance studies. Each stage lasts 4 to 10 days. There was no intervention in the first half of the experiment, and there was an intervention of iodized salt/non-iodized salt consumption in the second half of the experiment. The appropriate level of iodine intake for the elderly was explored by fitting and analyzing the dose change relationship between iodine intake and iodine excretion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Iodine intake intervention balance experiment | Other | Replace subjects' iodized salt with non-iodized salt. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Restrict subjects' intake of iodine-containing foods | Behavioral | Replace subjects' iodized salt with non-iodized salt. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Iodine intake | Daily iodine intake includes dietary iodine intake and drinking water iodine intake. | Each phase of the iodine balance study lasts 4 to 10 days. |
| Iodine excretion | Daily iodine excretion includes urinary iodine excretion and fecal iodine excretion. | Each phase of the iodine balance study lasts 4 to 10 days. |
| Measure | Description | Time Frame |
|---|---|---|
| thyroid function indexes | FT3、FT4、TSH、TPOAb、TGAb. Each subject was asked to collect venous blood twice (before the experiment and within one week after the intervention) to measure indicators of thyroid work. | Within one week before the start of the experiment. |
| thyroid volumn |
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The target population of this study is elderly people over 60 years old. Adults living in the same household can also participate.
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wenxing Guo, doctor | Contact | 18822024500 | guowenxing@tmu.edu.cn | |
| Zhangzhao Wang | Contact | 13821470215 | graik.wang@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Wenxing Guo | Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gansu provincial center for disease control and prevention | Recruiting | Lanzhou | Gansu | 730099 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25591468 | Background | Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95. doi: 10.1016/S2213-8587(14)70225-6. Epub 2015 Jan 13. | |
| 30891786 | Background | Farebrother J, Zimmermann MB, Andersson M. Excess iodine intake: sources, assessment, and effects on thyroid function. Ann N Y Acad Sci. 2019 Jun;1446(1):44-65. doi: 10.1111/nyas.14041. Epub 2019 Mar 20. |
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The data of the study are available from the project leader upon reasonable request.
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| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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When the first phase of the iodine balance study without intervention is completed. After an interval of 4 days, subjects who eat iodized salt will be included, the iodized salt will be replaced with non-iodized salt, and the second phase of the iodine balance experiment will begin.
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Thyroid volume was measured using thyroid B-ultrasound. |
| Within one week before the start of the experiment. |
| salivary iodine | Every time the subject urinates, 2ml of saliva is collected. | 4 to 10 days |
| blood pressure | Subjects had their blood pressure measured before and after the study. | Within one week before the start of the experiment. |
| fasting blood glucose | Subjects had their fasting blood glucose measured before and after the study. | Within one week before the start of the experiment. |
| Shandong provincial institute for endemic disease control | Recruiting | Jinan | Shandong | 250014 | China |
|
| Tianjin Medical University | Recruiting | Tianjin | Tianjin Municipality | 300070 | China |
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| 27465383 | Background | Dold S, Zimmermann MB, Baumgartner J, Davaz T, Galetti V, Braegger C, Andersson M. A dose-response crossover iodine balance study to determine iodine requirements in early infancy. Am J Clin Nutr. 2016 Sep;104(3):620-8. doi: 10.3945/ajcn.116.134049. Epub 2016 Jul 27. |
| 5762324 | Background | Malvaux P, Beckers C, De Visscher M. Iodine balance studies in nongoitrous children and in adolescents on low iodine intake. J Clin Endocrinol Metab. 1969 Jan;29(1):79-84. doi: 10.1210/jcem-29-1-79. No abstract available. |
| 4208456 | Background | Ingenbleek Y, Malvaux P. Iodine balance studies in protein-calorie malnutrition. Arch Dis Child. 1974 Apr;49(4):305-9. doi: 10.1136/adc.49.4.305. |
| Background | Chinese Nutrition Society. Chinese Dietary Reference Intakes. Beijing, People's Medical Publishing House. 2014: 230-237. Chinese. |
| 32624007 | Background | Yang L, Wang J, Yang J, Zhang H, Liu X, Mao D, Lu J, Gu Y, Li X, Wang H, Xu J, Tan H, Zhang H, Yu W, Tao X, Fan Y, Cai Q, Liu X, Yang X. An iodine balance study to explore the recommended nutrient intake of iodine in Chinese young adults. Br J Nutr. 2020 Dec 14;124(11):1156-1165. doi: 10.1017/S0007114520002196. Epub 2020 Jun 22. |
| 30526700 | Background | Tan L, Tian X, Wang W, Guo X, Sang Z, Li X, Zhang P, Sun Y, Tang C, Xu Z, Shen J, Zhang W. Exploration of the appropriate recommended nutrient intake of iodine in healthy Chinese women: an iodine balance experiment. Br J Nutr. 2019 Mar 14;121(5):519-528. doi: 10.1017/S0007114518003653. Epub 2018 Dec 11. |