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Dexmedetomidine is recommended over fentanyl as adjunctive medication to bupivacaine for saddle block spinal anesthesia in anal surgeries and procedures.
Objectives: A saddle spinal block is a viable choice for anal surgeries. This technique effectively maintains balanced hemodynamics, and fast recovery, and prevents irrelevant motor blocks in both limbs.
Methods: Fifty-eight adult patients were categorized into two groups. Group FENT, consisting of 29 patients, underwent a saddle block with hyperbaric bupivacaine (2.5 ml) combined with fentanyl (0.5 ml; 25 μg). The DEX Group, consisting of 29 patients, received 2.5 ml of hyperbaric bupivacaine mixed with dexmedetomidine (10 μg; 0.5 ml). Continuous monitoring of HR and SpO2 was conducted. Evaluation of sensory blockage and the motor block was done utilizing the Bromage scale. Following surgery, assessments were conducted. Pain in the ward and PACU was determined utilizing the visual analog scale (VAS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The FENT Group | Other | Group FENT, consisting of 29 patients, underwent a saddle block with hyperbaric bupivacaine (2.5 ml) combined with fentanyl (0.5 ml; 25 μg). |
|
| The DEX Group | Other | The DEX Group, consisting of 29 patients, received 2.5 ml of hyperbaric bupivacaine mixed with dexmedetomidine (10 μg; 0.5 ml). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FENT group | Drug | Group FENT, consisting of 29 patients, underwent a saddle block with hyperbaric bupivacaine (2.5 ml) combined with fentanyl (0.5 ml; 25 μg). |
|
| Measure | Description | Time Frame |
|---|---|---|
| the duration until the first call for analgesia | the duration until the first call for analgesia | 20 months |
| Measure | Description | Time Frame |
|---|---|---|
| the duration from spinal injection until reaching the maximal sensory level | the duration from spinal injection until reaching the maximal sensory level | 20 months |
| the duration needed for sensory regression to occur over two spinal segments from the maximal sensory level |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| sameh ha seyam, MD | assistant professor of anesthesiology, intensive care and pain management | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Al-Azhar faculty of medicine | Cairo | 12546 | Egypt |
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Fifty-eight adult patients were categorized into two groups. Group FENT, consisting of 29 patients, underwent a saddle block with hyperbaric bupivacaine (2.5 ml) combined with fentanyl (0.5 ml; 25 μg). The DEX Group, consisting of 29 patients, received 2.5 ml of hyperbaric bupivacaine mixed with dexmedetomidine (10 μg; 0.5 ml).
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The subjects were randomly categorized into two groups utilizing random numbers generated by computer software. A sealed envelope (containing the allocation numbers of groups) was opened at the time of patient enrollment.
|
| DEX group | Drug | The DEX Group, consisting of 29 patients, received 2.5 ml of hyperbaric bupivacaine mixed with dexmedetomidine (10 μg; 0.5 ml). |
|
|
the duration needed for sensory regression to occur over two spinal segments from the maximal sensory level |
| 20 months |
| the time required for sensory regression until reaching the S1 level (from the maximal sensory level) | the time required for sensory regression until reaching the S1 level (from the maximal sensory level) | 20 months |
| the duration from injection to achieving Bromage 0, the total tramadol consumption (until the first 24 hours) | the duration from injection to achieving Bromage 0, the total tramadol consumption (until the first 24 hours) | 20 months |
| side effects occurrences | side effects occurrences | 20 months |