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The study will be conducted to examine the effects of abnormal growth pattern and cerebrovascular blood flow measurements on fetal frontal lobe development with the advancing ultrasound technology. Antenatal assessment of frontal lobe development will enable clinicians to predict neurodevelopmental problems that may develop postnatally. In addition, this study will examine the effects of FGR on frontal lobe development.
Fetal growth restriction (FGR) affects up to 10% of all pregnancies. The International Society of Ultrasound in Obstetrics & Gynecology (ISUOG) adopts the Delphi consensus criteria for the definition of FGR. These criteria include estimated fetal weight (EFW) or abdominal circumference (AC) < 3rd percentile or EFW or AC < 10th percentile with abnormal Doppler findings or decreased growth percentiles. FGR is a cause of perinatal morbidity and mortality. These perinatal outcomes include cardiovascular, endocrine and neurodevelopmental disorders. Fetal growth restriction, which is associated with lower neurobehavioral test scores, is associated with significant postnatal costs for both the health care system and families. Previous literature has shown that three-dimensional ultrasonography of intracranial structures reveals significant differences between fetuses with FGR and gestational age-appropriate (AGA) fetuses. However, the limited use of three-dimensional ultrasonography has hindered clinical applications. The frontal Anterior-Posterior Diameter (FAPD)/Occipital-Frontal Diameter (OFD) ratio has recently been used to assess frontal lobe development in fetuses with congenital heart disease. The FAPD is obtained by measuring from the inner line of the frontal bone along the fetal brain midline to the posterior edge of the CSP. This measurement refers to the frontal lobe of the fetal cerebrum. This study was designed to investigate the FAPD/ OFD ratio and frontal lobe development in fetuses with FGR and to evaluate cerebrovascular flow and anterior midbrain structures in FGR fetuses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant Women with Fetal Growth Restriction | Fetuses with fetal growth restriction according to Delphi consensus criteria between 32-37 weeks of gestation |
| |
| Healthy Pregnancies | Normally developing fetuses between 32-37 weeks of gestation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound measurements | Diagnostic Test | Evaluation will be performed by ultrasonography. The following measurements will be taken with the ultrasonographic examination.
|
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasonographic measurements and comparison of fetuses with and without fetal growth retardation | Demographic data, ultrasonographically obtained biometric measurements, and Doppler flow data will be compared in both groups.
The main biometric measurement of the study will be comparison. The percentile values of the Anterior Cerebral Artery Doppler Pulsatility Index (cm/s) (ACA PI cm/s ) and Middle Cerebral Artery Doppler Pulsatility Index cm/s (MCA PI cm/s) will be calculated for the week of ultrasonographic measurement, and the ratio of ACA PI and MCA PI will be compared in fetuses with and without fetal growth retardation. | Prenatal (32-37 gestational weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of neonatal findings of the patients included in the study | Fetuses included in the study will be evaluated after delivery. Whether there is a need for Neonatal Intensive Care, APGAR scores, (0-10) Whether neonatal complications develop, will be evaluated and compared in the control group and in the group with fetal growth retardation. | through study completion, an average of 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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The study will include normally developing fetuses between 32-37 weeks of gestation and fetuses with fetal growth restriction.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Etlik City Hospital | Ankara | Yenimahalle | 06000 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39377442 | Derived | Ulusoy CO, Agaoglu RT, Sucu ST, Kurt DS, Bucak M, Seyhanli Z, Yucel KY. Evaluation of Anterior and Middle Brain Structures With Cerebrovascular Flow in Fetuses With Fetal Growth Restriction: A Prospective Study. J Clin Ultrasound. 2025 Feb;53(2):262-270. doi: 10.1002/jcu.23857. Epub 2024 Oct 8. |
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In accordance with hospital policy, it is not allowed to share data with third parties. If necessary, the chief researcher can be contacted
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| ID | Term |
|---|---|
| D005317 | Fetal Growth Retardation |
| ID | Term |
|---|---|
| D005315 | Fetal Diseases |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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|
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006130 | Growth Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |