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| Name | Class |
|---|---|
| Autism Discovery and Treatment Foundation | UNKNOWN |
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The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
Although neurodevelopmental disorders are very prevalent (for example Autism affects 1 out of every 36 children and dyslexia affects up to 15% of the population), the etiology of such disorders is not known. The purpose of this investigation is to identify common etiologies of neurodevelopmental disorders (i.e., speech delay, global developmental delay, autism) and determine if it is possible to find early indicators of the diagnosis and foster the potential for a better prognosis of these disorders. At this time the investigators examine patients with neurodevelopment disorders with various medical investigations, but the results of these investigations are not systematically evaluated. One of the goals of this research is to systematically examine this information in order to identify patterns of test abnormalities that have not been previously described. Another goal of this research is to identify the common etiologies typically identified by the medical evaluation, so we can further refine our approach. In addition, the investigators now have the ability to evaluate biological samples for biomarkers that have potential to be diagnostically useful.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autism | Children with autism will be followed in regards to their clinical management. | ||
| Mitochondrial Encephalopathy | Children with Mitochondrial Encephalopathy will be followed in regards to their clinical management. | ||
| Down Syndrome | Children with Down Syndrome will be followed in regards to their clinical management. | ||
| Cerebral Folate Deficiency | Children with Cerebral Folate Deficiency will be followed in regards to their clinical management. | ||
| PANS | Children with PANS will be followed in regards to their clinical management. | ||
| PANDAS | Children with PANDAS will be followed in regards to their clinical management. | ||
| Epilepsy | Children with Epilepsy will be followed in regards to their clinical management. |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Patients with Specific Medical abnormalities | It is unknown if a specific set of biological abnormalities contribute to the formation of many types of neurodevelopmental disorders. The study is intended to identify the relationship between biological abnormalities and neurodevelopmental disorders. The chart will be reviewed for medical diagnoses other than the primary neurodevelopmental disorders. | up to 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| The number of children with abnormal clinical lab | It is unknown if a abnormalities in specific clinical laboratories are associated with specific neurodevelopmental disorders. The study is intended to identify the relationship between biological abnormalities and neurodevelopmental disorders. The medical chart will be reviewed to determine the number of children with a specific medical disorder who have abnormalities in specific clinical labs. |
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Inclusion Criteria:
Neurodevelopmental delays Clinical visit at an Rossignol Medical Center
Exclusion Criteria:
-
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Children who present to Rossignol Medical Center for standard care related to neurodevelopmental disorders.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rossignol Medical Center | Recruiting | Phoenix | Arizona | 85050 | United States |
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| Label | URL |
|---|---|
| Rossignol Medical Center | View source |
| Autism Discovery and Treatment Foundation | View source |
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Deidentified IPD may be shared on a case by case basis
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Blood, urine, cerebrospinal fluid, muscle, and skin samples may be retained.
| ADHD | Children with ADHD will be followed in regards to their clinical management. |
| Dyslexia and other learning disabilities | Children with Dyslexia and other learning disabilities will be followed in regards to their clinical management. |
| Other Neurodevelopmental Disorders | Children with Other Neurodevelopmental Disorders will be followed in regards to their clinical management. |
| up to 7 years |
| The number of children who respond to specific treatments | Various behavioral and medical treatments are used for many types of neurodevelopmental disorders but the effectiveness for many of these treatments is not known. The study is intended to identify the relationship between biological abnormalities (and their treatments) and neurodevelopmental disorders. The medical chart will be review to determine the treatments applied to each participant and the participants response. | up to 7 years |
| ID | Term |
|---|---|
| D065886 | Neurodevelopmental Disorders |
| D000067877 | Autism Spectrum Disorder |
| C537163 | Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections |
| C000631768 | Pediatric acute-onset neuropsychiatric syndrome |
| D004314 | Down Syndrome |
| D004827 | Epilepsy |
| D017237 | Mitochondrial Encephalomyopathies |
| C567791 | Neurodegeneration Due To Cerebral Folate Transport Deficiency |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D002659 | Child Development Disorders, Pervasive |
| D008607 | Intellectual Disability |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D025063 | Chromosome Disorders |
| D030342 | Genetic Diseases, Inborn |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D017240 | Mitochondrial Myopathies |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D001928 | Brain Diseases, Metabolic |
| D009468 | Neuromuscular Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D028361 | Mitochondrial Diseases |
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