Dydrogesterone Versus GnRH Antagonist in Poor Responders... | NCT06212102 | Trialant

Dydrogesterone Versus GnRH Antagonist in Poor Responders... | NCT06212102 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Progestin primed ovarian stimulation group	Experimental	HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Progestin (dydrogesterone) 30 mg/day was used to prevent premature LH surge during the FPS and LPS. In subsequent cycle, frozen embryo transfer was done	Drug: Progestin primed ovarian stimulation
GnRH antagonist group	Active Comparator	HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Flexible GnRH antagonist protocol (Cetrorelix acetate) (0.2 mg) was used to prevent premature LH surge during the FPS and LPS. In subsequent cycle, frozen embryo transfer was done	Drug: GnRH antagonist

Interventions

Name	Type	Description	Arm Group Labels	Other Names
Progestin primed ovarian stimulation	Drug	HMG ( 300IU) was used during the follicular phase of ovarian stimulation (FPS) and during the luteal phase of ovarian stimulation (LPS). Progestin (dydrogesterone) 30 mg/day was used to prevent premature LH surge during the FPS and LPS.

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Medications costs per retrieved oocyte	Total cost of medications used in all cycles/number of retrieved oocytes	Ten to fifteen days after starting ovarian stimulation]

Secondary Outcomes

Measure	Description	Time Frame
Clinical pregnancy rate	Presence of intrauterine gestational sac detected by transvaginal ultrasound	5 weeks after embryo transfer]
Ongoing Pregnancy Rate	Pregnancies continued beyond 20 weeks gestation

Contacts/Locations Module

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
27020168	Background	Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L. Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation. Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.