Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis. Previous studies have shown that different components of the blink reflex, such as the latencies of homo- and contralateral R2 responses can be affected. Studies have found that a contralateral R1 component can appear in neurological diseases with affection of the central nervous system especially upper motor neuron, such as HTLV1 infection. Thus, you aim to determine if a contralateral R1 component could be present in ALS.

Inclusion Criteria:

For patients

• Aged 18 to 99 years old
• Referred for suspected motor neuromuscular disease
• Collection of non-opposition

For healthy subjects:

• Aged 18 to 99 years old
• Absence of any neurological pathology
• Collection of non-opposition

Exclusion Criteria:

• Previous damage linked to another cause of the cranial nerves
• Prior brainstem lesions
• Persons deprived of liberty by a judicial or administrative decision
• Patient under judicial protection, unable to express consent

Patients referred to the neurophysiology unit from the Hospices civils de Lyon, for a suspicion of motor neuron disease.

And healthy volunteers for the third group.