Clinical and Biochemical Evaluation of 1% Metformin in Non-surgical Treatment of Periodontitis

Clinical and Biochemical Evaluation of the Use of Locally Delivered Metformin as an Adjunctive Therapy to Non Surgical Periodontal Treatment of Periodontitis Patients (Randomized Controlled Study)

The aim of the study to evaluate the clinical and biochemical efficacy of 1% Metformin gel in treatment of periodontitis patients

Inclusion Criteria:

• Patients with Stage III Grade A Periodontitis.
• Systemically free according to the modified Burkitt's health history questionnaire, Group I. (Glick et al., 2021).
• Good compliance with the plaque control instructions following initial therapy.
• Availability for follow up and maintenance program.

Exclusion Criteria:

• Smokers
• Pregnant and lactating females.
• Vulnerable groups of patients' e.g (prisoners, handicapped patients and decisionally impaired individuals).