Microecology and Immunity in Patients With Anti-MDA5 Antibody Positive Dermatomyositis and Interstitial Lung Disease

Microecology and Host Immunity in Patients With Anti-melanoma Differentiation Associated Gene 5 Antibody Positive Dermatomyositis and Interstitial Lung Disease

The purpose of this study was to analyze the relationship between the microbial community, host immunity and the presence or absence of concurrent rapidly progressive interstitial lung disease patients with anti-MDA5 antibody positive dermatomyositis.

Methods: Bronchoalveolar lavage specimens of patients with anti-MDA5 antibody positive dermatomyositis and interstitial lung disease were collected and studied to analyze the relationship between the composition of patients' microecology and the occurrence and development of disease.

Inclusion Criteria:

• Patients who meet the diagnostic criteria of dermatomyositis and anti-MDA 5 antibody positive.
• Anti-MDA5 antibody positive DM patients with RPILD meet the diagnostic criteria for RPILD.
• Must have undergone bronchoalveolar lavage.
• Age≥18 years old.
• Patients who signed informed consent forms

Exclusion Criteria:

• Patients who had other connective tissue diseases.
• Patients with ILD or RPILD caused by infection, tumors, drugs, biochemistry and other factors.
• Pregnant or lactating patients.
• The patient also participated in any other clinical trial.
• Disagreement for inclusion in this study