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This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men. It aims to determine potential enhancements in sperm health to provide insights into male fertility and reproductive health improvement strategies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Supplement 1 | Experimental | Creatine monohydrate |
|
| Supplement 2 | Experimental | Creatine monohydrate plus ubiquinol |
|
| Placebo | Placebo Comparator | Inulin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Supplement 1 | Dietary Supplement | Creatine monohydrate (5 g/day) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sperm concentration | Number of sperm per milliliter of semen | Change from baseline sperm concentration at 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Total antioxidant capacity | Level of total antioxidant capacity in semen | Change from baseline total antioxidant capacity at 8 weeks |
| Creatine kinase | Level of creatine kinase in semen |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sergej Ostojic, MD, PhD | University of Novi Sad | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| FSPE Applied Bioenergetics Lab | Novi Sad | Vojvodina | 21000 | Serbia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35276945 | Background | Ostojic SM, Stea TH, Engeset D. Creatine as a Promising Component of Paternal Preconception Diet. Nutrients. 2022 Jan 28;14(3):586. doi: 10.3390/nu14030586. | |
| 41052075 | Derived | Nedeljkovic D, Todorovic N, Javorac D, Baltic S, Vranes M, Panic J, Kladar N, Ratgeber L, Betlehem J, Acs P, Stea TH, Engeset D, Stajer V, Ostojic SM. The effects of 8-week creatine supplementation with and without ubiquinol on sperm quality biomarkers in normospermic and oligospermic men: A randomized controlled pilot trial. Nutr Health. 2025 Oct 6:2601060251385000. doi: 10.1177/02601060251385000. Online ahead of print. |
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Data obtained through this study may be provided to qualified researchers with academic interest in sperm quality. Data will be coded, with no PHI included. Approval of the request and execution of all applicable agreements are prerequisites to the sharing of data with the requesting party.
Data requests can be submitted starting 9 months after article publication and the data will be made accessible for up to 24 months. Extensions will be considered on a case-by-case basis.
Only qualified researchers with academic interest in sperm quality
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| ID | Term |
|---|---|
| D009845 | Oligospermia |
| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| C000602145 | TARGET 1 dietary supplement |
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| Supplement 2 |
| Dietary Supplement |
Creatine monohydrate (5 g/day) plus ubiquinol (200 mg/day) |
|
| Placebo | Dietary Supplement | Placebo (inulin) |
|
| Change from baseline creatine kinase at 8 weeks |
| Creatine | Level of creatine in semen | Change from baseline creatine at 8 weeks |
| The World Health Organisation-Five Well-Being Index (WHO-5) | The World Health Organisation-Five Well-Being Index (WHO-5) is a short self-reported measure of current mental wellbeing.The raw scores are transformed to a score from 0 to 100, with lower scores indicating worse well-being. | Change from baseline WHO-5 at 8 weeks |
| D007246 |
| Infertility |
| D052801 | Male Urogenital Diseases |