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Aim of the study To determine the frequency misdiagnosis of cardiac congestion as interstitial lung disease based on initial High Resolution CT interpretation alone.
To identify specific HRCT findings that are more commonly associated with misdiagnosis versus correct diagnosis of the underlying condition.
To establish diagnostic criteria or HRCT patterns that distinguish cardiac congestion from interstitial lung disease
Observational study of 150 patients found that cardiac congestion was misdiagnosed as interstitial lung disease in 24% of cases on initial HRCT imaging alone. Echocardiography and clinical correlation were needed to make the correct diagnosis .
Misdiagnosis can lead to inappropriate treatment with immunosuppressive drugs which could exacerbate right heart failure in patients who actually have cardiac congestion. Correct diagnosis is important for prognosis and management.
Subtle findings like upper lobe predominance of opacities, septal lines and a mosaic attenuation pattern on HRCT favor interstitial lung disease, while diffuse ground glass with central and perihilar distribution favors cardiac congestion .
Associated findings on HRCT like enlarged cardiac silhouette, pleural and pericardial effusions help suggest the diagnosis of cardiac congestion over idiopathic interstitial pneumonia .
Integrating clinical data on risk factors for heart failure, echocardiography findings and follow-up imaging response to diuretic therapy can help differentiate the two conditions when HRCT is non-specific
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| Measure | Description | Time Frame |
|---|---|---|
| Accuracy of initial HRCT interpretation | (percentage of cases initially read as interstitial lung disease that were later found to be cardiac congestion) | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Time to correct diagnosis | Mean or median number of days/months between initial misdiagnosis on HRCT and reaching accurate diagnosis of cardiac congestion | baseline |
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Inclusion Criteria:
Exclusion Criteria:
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prospective observational study design. Inclusion of patients who underwent HRCT for suspected interstitial lung disease or cardiac congestion.
HRCT scans by experienced radiologists who are blinded to the initial interpretation and final diagnosis.
Development of specific diagnostic criteria or guidelines to differentiate between interstitial lung disease and cardiac congestion based on HRCT findings.
Collection of echocardiogram,lab results, clinical follow up to determine finial diagnosis.
Comparison of Initial HRCT Interpretation: Comparison of the initial HRCT interpretation with the final diagnosis to determine the rate of misdiagnosis.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hend saleh, MD | Contact | 01098988712 | hend.m.saleh@gmail.com | |
| Mohamed Abdalrahman, MD | Contact | 0102660007 | dr.mga2011@aun.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| marwan sayed, MD | lecture in cardiac diseases | Study Chair |
| samaa elkossi, MD | Lecture inradiology departement | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33121391 | Background | Nathan SD, Pastre J, Ksovreli I, Barnett S, King C, Aryal S, Ahmad K, Fukuda C, Ramalingam V, Chung JH. HRCT evaluation of patients with interstitial lung disease: comparison of the 2018 and 2011 diagnostic guidelines. Ther Adv Respir Dis. 2020 Jan-Dec;14:1753466620968496. doi: 10.1177/1753466620968496. | |
| 38007235 | Background |
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| Case AH, Beegle S, Hotchkin DL, Kaelin T, Kim HJ, Podolanczuk AJ, Ramaswamy M, Remolina C, Salvatore MM, Tu C, de Andrade JA. Defining the pathway to timely diagnosis and treatment of interstitial lung disease: a US Delphi survey. BMJ Open Respir Res. 2023 Nov 24;10(1):e001594. doi: 10.1136/bmjresp-2022-001594. |