Renal Impact of KAFTRIO in Mucoviscidose Population

Renal Impact of KAFTRIO in Mucoviscidose Population

The objective of this study is to describe the renal impact of Elexacaftor-Teacaftor-Ivacaftor, a triple modulator therapy of CFTR channel, in patients with cystic fibrosis. This new treatment acts on the CFTR channel, which is expressed at the level of the nephrons. The objective is to study the changes in plasma and urinary parameters, including metabolic explorations of urolithiasis, change in volemic parameters, renal function, urinary sediment and nutritional and glycemic parameters, in newly treated patients, through the data collected at introduction of the treatment and during the follow-up.

Inclusion Criteria:

• Patient with cystic fibrosis
• More than 18 years old
• Eligible for KAFTRIO

Exclusion Criteria:

• KAFTRIO contraindication
• Patient less than 18 years old
• Dialysis patient
• Pregnant woman
• Greffed patient
• Patient opposition to data collection