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The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.
The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective cohort | The cohort was retrospectively enrolled in The Sixth Affiliated Hospital, Sun Yat-sen University from August 2010 to August 2022. It is a training cohort. |
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| Prospective cohort | The same inclusion/exclusion criteria were applied for the same center prospectively. It is a validation cohort. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prediction model | Other | We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival | Overall survival was defined as the time from surgery to death, or to the last follow-up. | At least 3-year follow up |
| Disease-free survival | Disease-free survival was defined as the interval between surgery and the first peritoneal or distant relapse or death from any cause. | At least 1-year follow up |
| Peritoneal-free survival | Peritoneal-free survival was defined as the interval between surgery and the first peritoneal relapse. Ovarian metastasis has been shown to be a subtype of peritoneal metastasis. | At least 1-year follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Rates of key gene mutation | Rates of key gene mutation, such as microsatellite instability-high/DNA mismatch repair | At least 1-year follow up |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ovarian metastases from colorectal cancer
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yuanxin Zhang, MD | Contact | 8617372001179 | zyx163yxdz@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sixth Affiliated Hospital, Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510655 | China |
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| ID | Term |
|---|---|
| D007725 | Krukenberg Tumor |
| ID | Term |
|---|---|
| D018279 | Carcinoma, Signet Ring Cell |
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
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Primary tumor, metastatic tissue and normal tissue
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D018297 | Neoplasms, Cystic, Mucinous, and Serous |