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Niacinamide in lower concentrations has been recognized as a cosmetic ingredient with hydrating properties. Therefore, aim was to test the efficacy and safety of niacinamide cosmetic preparation in A Randomized, Controlled Trial.
Skin hydration (as use of hydrating cosmetic ingredients) is one of the most interventions for healthy skin and skin barrier function. Therefore, cosmetic ingredients used for this purpose should be examined for their efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| experimental arm | Experimental | Use of facial serum with niacinamide, plant-based collagen and peptides on randomized site on forehead |
|
| placebo comparator | Placebo Comparator | No treatment (usual skincare rutine) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| miss alice face it you love me serum | Other | Facial serum with niacinamide, plant-based collagen and peptides will be applied by each participant to the treatment site according to randomization protocol every evening |
| Measure | Description | Time Frame |
|---|---|---|
| TEWL assessment with Courage Khazaka probe | Transepidermal water loss | through study completion, an average of 1 year |
| Hydration assessment with corneometer probe | stratum corneum hydration | through study completion, an average of 1 year |
| pigmentation assessment with mexameter probe | erythema and melanin | through study completion, an average of 1 year |
| skin oiliness assessment with sebumeter probe | sebum level | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| subjective opinion of participants | participants notes on skin rection | through study completion, an average of 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Josipa Bukic | Contact | 00385917933752 | jbukic@mefst.hr |
| Name | Affiliation | Role |
|---|---|---|
| Dario Leskur | USSM | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Split School of Medicine | Recruiting | Split | Croatia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39768384 | Derived | Rusic D, Ivic M, Slugan A, Leskur D, Modun D, Durdov T, Vukovic D, Bukic J, Bozic J, Seselja Perisin A. Pilot Study on the Effects of a Cosmetic Serum Containing Niacinamide, Postbiotics and Peptides on Facial Skin in Healthy Participants: A Randomized Controlled Trial. Life (Basel). 2024 Dec 18;14(12):1677. doi: 10.3390/life14121677. |
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upon request
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| ID | Term |
|---|---|
| D017495 | Hyperpigmentation |
| D004485 | Eczema |
| ID | Term |
|---|---|
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D003872 | Dermatitis |
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| No treatment (usual skincare rutine) | Other | No treatment (usual skincare rutine) |
|
| D017443 |
| Skin Diseases, Eczematous |