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| Name | Class |
|---|---|
| Center of New Medical Technologies | OTHER |
| Triangel Scientific | INDUSTRY |
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This randomized, double-blind, placebo-controlled trial assessed the impact of a dietary fiber supplement (glucomannan, inulin, and psyllium) on weight and metabolic parameters in individuals with obesity-related genetic polymorphisms (FTO, MC4R, LEP, LEPR). Participants were adults aged 18-65 with a BMI ≥ 25 and confirmed genetic predispositions. The study, involving 216 participants (108 per group), ran over 12 weeks with assessments at 0, 4, 8, and 12 weeks. Primary outcome was Body-weight change in %. The study aimed to clarify the role of fiber supplements in genetically predisposed obese individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fiber Supplementation | Experimental | The active powder contained 1g glucomannan, 1g inulin, and 3g psyllium per bag. |
|
| Placebo group | Placebo Comparator | The placebo powder composed of maltodextrin and rice flour, carefully selected to mimic the texture and volume of the active powder without providing any active dietary fiber |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| glucomannan, inulin, and psyllium | Dietary Supplement | the subjects recieved fiber supplement containing glucomannan, inulin, and psyllium |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body-weight change in % | 180 days |
| Measure | Description | Time Frame |
|---|---|---|
| body-weight reduction ≥5% | 180 days | |
| body-weight reduc-tion ≥10% | 180 days | |
| Body weight in kg |
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Inclusion Criteria:
Exclusion Criteria:
- BMI < 25
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center of New Medical Technologies | Novosibirsk | Novosibisk Region | 630090 | Russia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38398881 | Result | Pokushalov E, Ponomarenko A, Garcia C, Pak I, Shrainer E, Seryakova M, Johnson M, Miller R. The Impact of Glucomannan, Inulin, and Psyllium Supplementation (SolowaysTM) on Weight Loss in Adults with FTO, LEP, LEPR, and MC4R Polymorphisms: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024 Feb 17;16(4):557. doi: 10.3390/nu16040557. |
| Label | URL |
|---|---|
| 10.3390/nu16040557 | View source |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| C022901 | (1-6)-alpha-glucomannan |
| D007444 | Inulin |
| D011620 | Psyllium |
| ID | Term |
|---|---|
| D013213 | Starch |
| D005936 | Glucans |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 |
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| placebo | Other | the subjects recieved placebo |
|
| 180 days |
| Body mass index change in % | 180 days |
| Fat mass change in % | 180 days |
| Systolic blood pressure in mmHg | 180 days |
| Fat-free mass change in kg | 180 days |
| Visceral fat rating change from baseline | 180 days |
| Diastolic blood pressure in mmHg | 180 days |
| Total cholesterol ratio | 180 days |
| LDL-C ratio | 180 days |
| HDL-C ratio | 180 days |
| Triglycerides ratio | 180 days |
| hsCRP ratio | 180 days |
| Fasting plasma glucose mmol/l | 180 days |
| Side effects % | any side effects or adverse events reported by subjects | 180 days |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Macromolecular Substances |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D005630 | Fructans |
| D011134 | Polysaccharides |
| D010936 | Plant Extracts |
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |