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| Name | Class |
|---|---|
| LUCAS BATISTELLA, MD | UNKNOWN |
| Kheira hireche, MD | UNKNOWN |
| Ludovic CANAUD, MD PhD | UNKNOWN |
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While surgery with anatomic reconstruction of prosthetic aortic infections and native infectious aortitis has become established over time, the ideal substitute is not clearly defined. The cryopreserved arterial allograft (AAC) recognized as resistant to infections not only presents availability problems making its use complicated, particularly in emergencies, with a certain number of long-term aneurysmal developments. The tubulized pericardium patch (PP), available in all cases, seems to give promising results in recent literature. The investigators propose a comparative study of these two substitutes in this indication.
We carried out a two-center observational study including retrospectively from January 2010 to July 2023 all patients operated on for aortic prosthesis infection and native infectious aortitis with AAC reconstruction and prospectively PP patch reconstructions from July 2018 to July 2023. The diagnosis of infection was established according to the MAGIC criteria. The patients' preoperative comorbidities were collected to compare the groups. Postoperative morbidity and mortality was then compared. The medium-term evaluation consisted of comparing according to the Kaplan Meier method: postoperative mortality, permeability, reinfection rate, reoperation rate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cryopreserved arterial allograft | Aortic infection treated by cryopreserved arterial allograft |
| |
| Rolled pericardium patch | Aortic infection treated by Pericardium patch rolled |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Explantation of a previous aortic graft or endograft and reconstruction by arterial allograft or rolled pericardium | Procedure | In situ reconstruction with explantation of the infected graft or endograft and reconstruction by allograft or pericardium |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Number of patients death during post operative stay | day 30 post operative |
| Reintervention | Rate of reintervention during post operative stay | 30 days, 6 months, 12 months, 24 months |
| Post operative Major cardiovascular adverse events (MACE) | Rate of nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death | day 30 post operative |
| Measure | Description | Time Frame |
|---|---|---|
| Permeability | Rate of reintervention for occlusion of the patch or the allograft | 30 days, 6 months, 12 months, 24 months |
| Reinfection | Rate of reintervention for infection of the patch or the allograft |
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Inclusion Criteria:
Exclusion Criteria:
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patients operated on for a native infection or an aortic prosthesis who had pericardium or allograft reconstruction
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40122311 | Derived | Battistella L, Kireche R, Ricco JB, Boisroux T, Shourick J, Chaufour X, Canaud L, Hostalrich A. Outcomes of native or graft abdominal aortic infection managed with orthotopic xeno pericardial grafts or cryopreserved allograft. J Vasc Surg. 2025 Jul;82(1):90-101.e3. doi: 10.1016/j.jvs.2025.03.182. Epub 2025 Mar 22. |
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| 30 days, 6 months, 12 months, 24 months |
| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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