LSM and SSM for the Diagnosis of CSPH: a Prospective Cohort Study

Diagnosing and Monitoring Portal Hypertension Non-invasively Using Spleen Stiffness Measurement in Patients With Advanced Chronic Liver Disease: a Prospective Cohort Study

The goal of this observational study is to assess non-invasive tools' efficacy in predicting portal hypertension-related complications in individuals with advanced chronic liver disease. The main question it aims to answer are:

- what are the cut-off values for non-invasive tests (NITs) (including LSM, SSM) that predict the presence and occurrence of hepatic decompensation in individuals with advanced chronic liver disease?

Participants will undergo regular study visits involving non-invasive tests (LSM, SSM) and assessments to monitor hepatic decompensation over the study period.

Inclusion Criteria:

• Age above 18years old
• Advanced chronic liver disease (defined as LSM ≥ 10kPa)
• Ability to provide informed consent

Exclusion Criteria:

• Transjugular intrahepatic portosystemic shunt
• previous liver transplantation
• Abnormality of the porto-mesenteric system (portal vein thrombosis, splenic vein thrombosis, splenectomy, portal cavernomatous transformation, porto-caval shunts)
• Hematological malignancy