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The goal of this observational study is to assessing the global variation in patient characteristics, management, and outcomes in those undergoing trauma laparotomy.
The main questions it aims to answer are:
This is a purely observational study on patients undergoing trauma laparotomy, with no direct change to clinical care.
We will conduct a prospective multi-centre observational cohort study of patients undergoing a trauma laparotomy. We will recruit centres through pre-existing research networks, utilising a snowballing technique to expand registration of centres. We will enrol eligible patients undergoing emergency trauma laparotomy over a consecutive 30 day period at individual centres during the study dates, with patients followed until discharge, death, or 30 days post-operatively, whichever comes first. All data will be submitted to a central study team by 30 days after the end of their respective data study period.
Any hospital worldwide that performs emergency trauma surgery will be eligible to participate, including both trauma centres and trauma units; a minimum of 1 case must be submitted by the centre during the 30 day study period to be eligible. Each centre's team will be comprised of a local study lead, with maximum 3 members of the local study team for each data collection period. Independent data validators will be also required for select centres.
We will include patients of all ages who present to hospital with a blunt or penetrating injury and undergo a trauma laparotomy within 5 days of presentation to the treating centre (day 0 being time of presentation). A patient will be included for final analysis if >70% of the data points required have been recorded.
Exclusion criteria are:
We aim to collect system, patient, process, and outcome data. A data set will be collected on all patients undergoing a trauma laparotomy within the inclusion period. The included data fields were based on work by similar studies and refined through iterative consultation with a global interdisciplinary consortium of clinicians involved in trauma care.
Data will be collected through access to patient records only at each centre, performed by members of the local study team. The patient will not be contacted directly in any capacity during their inpatient stay or after the study and no direct involvement in patient care will occur. Data will be collected directly onto a well-established secure web-based system, REDCap cloud (or recorded temporarily onto a hard copy Data Collection Form and uploaded to REDCap at a later date)
The data collected will include a pragmatic set of variables that allow the proposed research to be conducted, but minimise both risk of identification and exclude extraneous possibly sensitive medical information. Local requisite ethics and approvals will be applied for and be in place before any data collection occurs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Trauma Laparotomy Patients | Patients of all ages who present to hospital with a blunt or penetrating injury and undergo a trauma laparotomy within 5 days of presentation to the treating centre |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trauma Laparotomy | Procedure | Emergency abdominal surgery through midline incision to access abdominal and / or pelvic organs, to access identified injuries or exploratory diagnostic reasons |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | All cause 30-day post-operative mortality rate | 30 days post-operatively |
| Measure | Description | Time Frame |
|---|---|---|
| Length of Hospital Stay | Time in hospital, from the operation until discharge | 30 days post-operatively |
| Morbidity Rates | Any post-operative morbidity that occurred to the patient, as defined by the adapted Clavien-Dindo in trauma scale |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing a trauma laparotomy for either a blunt or penetrating injury within 5 days of presenting to the treating centre.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael F Bath, MBChB | Contact | +44 (0)1223748577 | mb2583@cam.ac.uk | |
| Tom Bashford, PhD | Contact | tb508@cam.ac.uk |
| Name | Affiliation | Role |
|---|---|---|
| Tom Bashford, PhD | University of Cambridge | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42107384 | Derived | Aziz R, Bath MF, Abdelmohsen SM, Chukwu I, Saleh R, Caceres E, Nuno-Guzman CM, Amoako J, Nagraj S, Karusoke DK, Hobbs L, Smith BG, Kohler K, Hardcastle TC, Perkins ZB, Weiser TG, Lakhoo K, Bashford T; GOAL-Trauma Collaborative. Global variation in injury patterns, interventions, and post-operative outcomes for children and adolescents undergoing trauma laparotomy: an international cohort study. Lancet Child Adolesc Health. 2026 Jul;10(7):505-514. doi: 10.1016/S2352-4642(26)00069-6. Epub 2026 May 7. | |
| 41938841 |
| Label | URL |
|---|---|
| Main Study Website | View source |
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| ID | Term |
|---|---|
| D000007 | Abdominal Injuries |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| 30 days post-operatively |
| Discharge Destination | At time of discharge or stepdown from hospital, location the patient was discharged | 30 days post-operatively |
| Derived |
| Ng WH, Bath MF, Amoako J, Kohler K, Baderhabusha DU, Caceres E, Nuno-Guzman CM, Moonesinghe R, Hobbs L, Smith BG, Weiser TG, Hardcastle TC, Perkins ZB, Bashford T; GOAL-Trauma Collaborative. Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study. EClinicalMedicine. 2026 Mar 4;93:103814. doi: 10.1016/j.eclinm.2026.103814. eCollection 2026 Mar. |
| 40972623 | Derived | Bath MF, Amoako J, Kohler K, Hashi AS, Zhang Z, Baderhabusha DU, Caceres E, Nuno-Guzman CM, Marsden M, Carenzo L, Khajanchi M, Saleh R, Edmiston T, Hammer C, Hobbs L, Smith BG, Hutchinson P, Weiser TG, Perkins ZB, Hardcastle TC, Bashford T; GOAL-Trauma Collaborative. Global variation in patient factors, interventions, and postoperative outcomes for those undergoing trauma laparotomy: an international, prospective, observational cohort study. Lancet Glob Health. 2025 Nov;13(11):e1837-e1848. doi: 10.1016/S2214-109X(25)00303-1. Epub 2025 Sep 16. |