The Diagnostic and Prognostic Value of Presepsin in Sepsis

PRESEPSIN: Biomarker in the Early Diagnosis of Sepsis

Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment.

No studies compared presepsin to procalcitonin and endotoxin in patients treated with by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).

Intra-abdominal infections are a common cause of sepsis and frequently occur in intensive care unit (ICU) patient. Various markers such as procalcitonin, presepsin and endotoxin are used to identify patients at risk of sepsis or to guide proper treatment. Particularly, endotoxin can be removed from the blood by extracorporeal hemoperfusion with a polymyxin-B-adsorbing cartridge (PMX-HA).

No studies compared presepsin to procalcitonin and endotoxin in patients treated with PMX-HA. The investigators aim to evaluate the trend and prognostic value of presepsin versus procalcitonin and endotoxin in ICU patients with septic shock from complicated major abdominal surgery, treated with PMX-HA.

Inclusion Criteria:

• caucasian patients
• patients undergoing laparoscopic major abdominal surgery

Exclusion Criteria:

• pregnancy,
• organ transplantation,
• palliative care
• metastatic cancer
• head trauma and polytrauma
• coagulopathies
• use of anticoagulants
• neurological disease
• autoimmune disease
• thyroid disease.