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Lugol's solution and other preparations containing iodide have been used as an adjuvant treatment in patients with toxic disease planned for thyroidectomy. However, no conclusive evidence supporting the benefits of preoperative treatment with LS for patients with toxic goiters. This trial aims to provide new insights into future recommendations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Thyroidectomy without lugols solution preparation | No Intervention | euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, no preoperative preparation with 5% lugols solution | |
| Thyroidectomy with lugols solution preparation | Experimental | euthyroid patients undergoing total thyroidectomy for toxic thyroid disease, preoperative preparation with 5% lugols solution for 10 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lugol's iodine solution 5% | Dietary Supplement | 4 drops of LS every 8 hours for 10 days preoperatively will be given |
|
| Measure | Description | Time Frame |
|---|---|---|
| Thyroidectomy complications rate | postoperative bleeding, hypoparathyroidism and recurrent laryngeal nerve palsy will be recorded | 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid volume | via ultrasound | Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |
| Superior thyroid artery blood flow |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Styliani Laskou | 3rd Surgical Department of Aristotle University, AHEPA University Hospital, Thessaloniki | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 3rd Surgical Department of Aristotle University, AHEPA University Hospital, Thessaloniki | Thessaloniki | Thessaloniki | 54352 | Greece |
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| ID | Term |
|---|---|
| D013971 | Thyrotoxicosis |
| ID | Term |
|---|---|
| D006980 | Hyperthyroidism |
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
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via ultrasound
| Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |
| Fibrinogen | Sera, stored at -80 C until they were used | Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |
| Vascular endothelial growth factor | Sera, stored at -80 C until they were used | Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |
| Interleukin-16 serum levels | Sera, stored at -80 C until they were used | Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |
| Thromboelastography | Thromboelastography assay | Pre-intervention and immediately after the intervention for the lugols solution group. Only preoperative measurement for the non lugols solutiongroup. |