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Question: How effective is folic acid-fortified iodized salt in increasing serum folate concentrations among non-pregnant and non-lactating women of reproductive age? Hypothesis: Folic acid-fortified iodized salt can increase serum folate levels and serve as a policy consideration in salt fortification with both iodine and folic acid to reduce serious and fatal birth defects.
Salt is an ideal vehicle for fortification because its universal consumption and often centrally processed with established distribution channels. Over 70% of households globally have access to iodized salt. Considering the success of salt iodization, it is logical to use the existing infrastructure to provide folic acid through this dietary mechanism.
AIM:To assess increase in blood folate concentrations among women of reproductive age after they consume folic acid-fortified iodized salt.
OBJECTIVES :
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Folic acid fortified iodized salt | Dietary Supplement | addition of folic acid to iodized salt to be consumed daily and assess rise in serum folate levels. |
| Measure | Description | Time Frame |
|---|---|---|
| Measure changes in median serum folate levels between baseline and study endpoint | evaluate blood levels pre- and post-intake of study salt (fortified with folic acid) | 2-6 months |
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Inclusion Criteria: • Willing to voluntarily participate in the study
Exclusion Criteria:
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Women of childbearing age who are non-lactating and willing to consume the study salt for the duration were recruited for voluntary participation into the study.
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| Name | Affiliation | Role |
|---|---|---|
| Jogi Pattisapu, MD | Pediatric Neurosurgery | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pediatric Neurosurgery | Orlando | Florida | 32827 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38457177 | Derived | Pattisapu JV, Manda VV, Kottakki MNR, Kajana PM, Kancherla V, Bhaganagarapu HR, Veerappan V, Ediga A, Mannar V, Diosady L, Oakley GP Jr. Folic Acid-Fortified Iodized Salt and Serum Folate Levels in Reproductive-Aged Women of Rural India: A Nonrandomized Controlled Trial. JAMA Netw Open. 2024 Mar 4;7(3):e241777. doi: 10.1001/jamanetworkopen.2024.1777. |
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redacted information will be made available upon request.
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| ID | Term |
|---|---|
| D009436 | Neural Tube Defects |
| D005494 | Folic Acid Deficiency |
| D016135 | Spinal Dysraphism |
| C536410 | Neural tube defects X-linked |
| ID | Term |
|---|---|
| D009421 | Nervous System Malformations |
| D009422 | Nervous System Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| D014804 | Vitamin B Deficiency |
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |